STAP-2 Is a Novel Positive Regulator of TCR-Proximal Signals.
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
01 07 2022
01 07 2022
Historique:
received:
22
10
2021
accepted:
19
04
2022
pubmed:
21
6
2022
medline:
2
7
2022
entrez:
20
6
2022
Statut:
ppublish
Résumé
TCR ligation with an Ag presented on MHC molecules promotes T cell activation, leading to the selection, differentiation, and proliferation of T cells and cytokine production. These immunological events are optimally arranged to provide appropriate responses against a variety of pathogens. We here propose signal-transducing adaptor protein-2 (STAP-2) as a new positive regulator of TCR signaling. STAP-2-deficient T cells showed reduced, whereas STAP-2-overexpressing T cells showed enhanced, TCR-mediated signaling and downstream IL-2 production. For the mechanisms, STAP-2 associated with TCR-proximal CD3ζ immunoreceptor tyrosine activation motifs and phosphorylated LCK, resulting in enhancement of their binding after TCR stimulation. In parallel, STAP-2 expression is required for full activation of downstream TCR signaling. Importantly, STAP-2-deficient mice exhibited slight phenotypes of CD4
Identifiants
pubmed: 35725273
pii: jimmunol.2101014
doi: 10.4049/jimmunol.2101014
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
Receptors, Antigen, T-Cell
0
STAP2 protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
57-68Informations de copyright
Copyright © 2022 by The American Association of Immunologists, Inc.