Current understanding of the role of tyrosine kinase 2 signaling in immune responses.
Cytokines
Immune system
Inflammation
Signal transduction
Tyrosine kinase 2
Journal
World journal of biological chemistry
ISSN: 1949-8454
Titre abrégé: World J Biol Chem
Pays: United States
ID NLM: 101546471
Informations de publication
Date de publication:
27 Jan 2022
27 Jan 2022
Historique:
received:
27
03
2021
revised:
06
08
2021
accepted:
22
12
2021
entrez:
7
2
2022
pubmed:
8
2
2022
medline:
8
2
2022
Statut:
ppublish
Résumé
Immune system is a complex network that clears pathogens, toxic substrates, and cancer cells. Distinguishing self-antigens from non-self-antigens is critical for the immune cell-mediated response against foreign antigens. The innate immune system elicits an early-phase response to various stimuli, whereas the adaptive immune response is tailored to previously encountered antigens. During immune responses, B cells differentiate into antibody-secreting cells, while naïve T cells differentiate into functionally specific effector cells [T helper 1 (Th1), Th2, Th17, and regulatory T cells]. However, enhanced or prolonged immune responses can result in autoimmune disorders, which are characterized by lymphocyte-mediated immune responses against self-antigens. Signal transduction of cytokines, which regulate the inflammatory cascades, is dependent on the members of the Janus family of protein kinases. Tyrosine kinase 2 (Tyk2) is associated with receptor subunits of immune-related cytokines, such as type I interferon, interleukin (IL)-6, IL-10, IL-12, and IL-23. Clinical studies on the therapeutic effects and the underlying mechanisms of Tyk2 inhibitors in autoimmune or chronic inflammatory diseases are currently ongoing. This review summarizes the findings of studies examining the role of Tyk2 in immune and/or inflammatory responses using
Identifiants
pubmed: 35126866
doi: 10.4331/wjbc.v13.i1.1
pmc: PMC8790287
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1-14Informations de copyright
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Références
J Exp Med. 1998 Jan 5;187(1):79-87
pubmed: 9419213
Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):E5825-33
pubmed: 26460049
Nat Rev Dis Primers. 2019 Jul 4;5(1):45
pubmed: 31273209
Nat Immunol. 2018 Apr;19(4):354-365
pubmed: 29563620
Curr Opin Immunol. 2009 Oct;21(5):487-92
pubmed: 19717292
Am J Hum Genet. 2012 Apr 6;90(4):636-47
pubmed: 22482804
Arthritis Res Ther. 2010;12(1):R32
pubmed: 20181277
Nat Rev Drug Discov. 2018 May;17(5):353-377
pubmed: 29545548
Nature. 2005 Apr 28;434(7037):1144-8
pubmed: 15793561
Nat Protoc. 2006;1(5):2512-6
pubmed: 17406499
J Immunol. 2009 Dec 1;183(11):7539-46
pubmed: 19917699
Nature. 2016 Nov 30;540(7631):S1
pubmed: 27902684
Cell. 1996 Feb 9;84(3):443-50
pubmed: 8608598
Science. 1997 Sep 12;277(5332):1630-5
pubmed: 9287210
Nature. 1993 Nov 11;366(6451):129-35
pubmed: 8232552
Blood. 2007 Jul 15;110(2):553-60
pubmed: 17395783
Nature. 1988 Jun 9;333(6173):571-3
pubmed: 3259677
Science. 1995 Nov 3;270(5237):800-2
pubmed: 7481769
Cell. 1997 Jun 27;89(7):1067-76
pubmed: 9215629
Nat Rev Drug Discov. 2017 Dec 28;17(1):78
pubmed: 29282366
Cell. 1998 May 1;93(3):385-95
pubmed: 9590173
Immunity. 2001 Jun;14(6):727-37
pubmed: 11420043
Immunity. 2019 Apr 16;50(4):832-850
pubmed: 30995502
Nature. 2009 Apr 30;458(7242):1185-90
pubmed: 19322177
J Immunol. 2007 Sep 15;179(6):4135-41
pubmed: 17785852
Nature. 1995 Oct 19;377(6550):591-4
pubmed: 7566171
Immunity. 2000 Nov;13(5):715-25
pubmed: 11114383
N Engl J Med. 2018 Oct 4;379(14):1313-1321
pubmed: 30205746
J Immunol. 2001 May 1;166(9):5720-5
pubmed: 11313414
Cell. 1998 May 1;93(3):373-83
pubmed: 9590172
J Exp Med. 2008 Apr 14;205(4):751-8
pubmed: 18362173
Nature. 1980 Feb 14;283(5748):666-8
pubmed: 6153460
J Immunol. 2007 Oct 1;179(7):4313-7
pubmed: 17878325
J Immunol. 2017 Jan 15;198(2):767-775
pubmed: 27920272
Int Immunol. 2004 Aug;16(8):1173-9
pubmed: 15226272
Immunity. 2000 Oct;13(4):561-71
pubmed: 11070174
Nature. 1995 Sep 7;377(6544):65-8
pubmed: 7659163
Immunity. 2013 Mar 21;38(3):450-60
pubmed: 23453632
J Immunol. 2004 Mar 1;172(5):2827-33
pubmed: 14978083
Immunity. 2012 Feb 24;36(2):166-74
pubmed: 22365663
J Immunol. 2002 Nov 1;169(9):4707-11
pubmed: 12391177
Immunity. 2012 Apr 20;36(4):503-14
pubmed: 22520844
Immunity. 2000 Oct;13(4):549-60
pubmed: 11070173
Nature. 2007 Feb 22;445(7130):866-73
pubmed: 17314973
Nat Rev Mol Cell Biol. 2001 May;2(5):378-86
pubmed: 11331912
Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10088-10093
pubmed: 30224457
BMC Genomics. 2010 Mar 25;11:199
pubmed: 20338026
Gastroenterol Res Pract. 2010;2010:641865
pubmed: 20634907
Nat Rev Immunol. 2009 Feb;9(2):91-105
pubmed: 19151746
Cell. 1996 Feb 9;84(3):431-42
pubmed: 8608597
Science. 1994 Jun 3;264(5164):1415-21
pubmed: 8197455
Nat Immunol. 2011 Oct 30;12(12):1167-75
pubmed: 22037600
Nat Rev Immunol. 2002 Jan;2(1):37-45
pubmed: 11905836
Nat Rev Dis Primers. 2020 Sep 10;6(1):74
pubmed: 32913180
Proc Natl Acad Sci U S A. 1995 Aug 1;92(16):7307-11
pubmed: 7638186
Nat Commun. 2015 May 05;6:7001
pubmed: 25939698
Annu Rev Immunol. 2009;27:485-517
pubmed: 19132915
Drugs. 2017 Dec;77(18):1987-2001
pubmed: 29139090
J Immunol. 2002 Jun 1;168(11):5699-708
pubmed: 12023369
Curr Opin Rheumatol. 2001 May;13(3):191-2
pubmed: 11333347
Nat Rev Dis Primers. 2020 Apr 2;6(1):22
pubmed: 32242028
Nat Med. 1996 May;2(5):561-6
pubmed: 8616716
Nat Immunol. 2003 May;4(5):471-7
pubmed: 12679810
Annu Rev Immunol. 1989;7:145-73
pubmed: 2523712
Immunohorizons. 2019 May 16;3(5):172-185
pubmed: 31356171
J Immunol. 2001 May 1;166(9):5712-9
pubmed: 11313413
Nature. 2007 Feb 8;445(7128):648-51
pubmed: 17187052
Dermatol Online J. 1999 May;5(1):7
pubmed: 10673450
J Biol Chem. 2005 Jan 14;280(2):1678-87
pubmed: 15522867
Annu Rev Immunol. 1990;8:579-621
pubmed: 2188675
Nature. 2008 Jun 19;453(7198):1051-7
pubmed: 18563156
J Immunol. 2006 Jul 15;177(2):1160-70
pubmed: 16818774
J Biol Chem. 2013 Jun 28;288(26):19250-9
pubmed: 23658019
Immunity. 2006 Nov;25(5):745-55
pubmed: 17088085
J Invest Dermatol. 2018 Jun;138(6):1439-1442
pubmed: 29339122
Adv Drug Deliv Rev. 2007 Sep 30;59(11):1073-83
pubmed: 17825455
Science. 1995 Nov 3;270(5237):797-800
pubmed: 7481768
Rheumatology (Oxford). 2019 Feb 1;58(Suppl 1):i17-i26
pubmed: 30806707
Sci Signal. 2018 Oct 09;11(551):
pubmed: 30301788
J Immunol. 2002 Sep 1;169(5):2643-7
pubmed: 12193736
Immunity. 2002 Jun;16(6):755-8
pubmed: 12121657
J Immunol. 2011 Feb 1;186(3):1495-502
pubmed: 21172868
Immunity. 2000 Dec;13(6):795-804
pubmed: 11163195
Int Immunol. 2016 Sep;28(9):443-52
pubmed: 26944069
J Immunol. 2009 Jun 15;182(12):7776-83
pubmed: 19494301
Cell. 1992 Jul 24;70(2):313-22
pubmed: 1386289
Drugs. 2018 May;78(7):761-772
pubmed: 29687421
J Exp Med. 1995 Jan 1;181(1):399-404
pubmed: 7528775
J Immunol. 2009 May 1;182(9):5836-45
pubmed: 19380832
Ther Adv Hematol. 2013 Feb;4(1):15-35
pubmed: 23610611