Tuning IgE: IgE-Associating Molecules and Their Effects on IgE-Dependent Mast Cell Reactions.
CD23
FcεRI
IgE
basophils
glycosylation
histamine-releasing factor (HRF)
mast cells
omalizumab
structure
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
05 07 2021
05 07 2021
Historique:
received:
07
06
2021
revised:
30
06
2021
accepted:
02
07
2021
entrez:
7
8
2021
pubmed:
8
8
2021
medline:
27
10
2021
Statut:
epublish
Résumé
The recent emergence of anti-immunoglobulin E (IgE) drugs and their candidates for humans has endorsed the significance of IgE-dependent pathways in allergic disorders. IgE is distributed locally in the tissues or systemically to confer a sensory mechanism in a domain of adaptive immunity to the otherwise innate type of effector cells, namely, mast cells and basophils. Bound on the high-affinity IgE receptor FcεRI, IgE enables fast memory responses against revisiting threats of venoms, parasites, and bacteria. However, the dysregulation of IgE-dependent reactions leads to potentially life-threatening allergic diseases, such as asthma and anaphylaxis. Therefore, reactivity of the IgE sensor is fine-tuned by various IgE-associating molecules. In this review, we discuss the mechanistic basis for how IgE-dependent mast cell activation is regulated by the IgE-associating molecules, including the newly developed therapeutic candidates.
Identifiants
pubmed: 34359869
pii: cells10071697
doi: 10.3390/cells10071697
pmc: PMC8305778
pii:
doi:
Substances chimiques
Galectins
0
Receptors, IgE
0
Immunoglobulin E
37341-29-0
Histamine
820484N8I3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : The Ministry of Education, Culture, Sports, Science and Technology, Japan
ID : 20K08808, 17K10253, 20H03721
Organisme : The Promotion and Mutual Aid Corporation for Private Schools of Japan
ID : Grant-in-Aid for Special Research in Subsidies for ordinary expenses of private schools
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