RGS5 Attenuates Baseline Activity of ERK1/2 and Promotes Growth Arrest of Vascular Smooth Muscle Cells.

Animals Blood Pressure Calcium / metabolism Cell Cycle Checkpoints Cell Movement Cell Proliferation Diastole GTP-Binding Protein alpha Subunits, Gi-Go / metabolism Humans Mice, Inbred C57BL Mitogen-Activated Protein Kinase 1 / metabolism Mitogen-Activated Protein Kinase 3 / metabolism Muscle, Smooth, Vascular / cytology Myocytes, Smooth Muscle / metabolism Phosphorylation RGS Proteins / metabolism Spheroids, Cellular / metabolism Systole rhoA GTP-Binding Protein / metabolism
ERK1/2 G-protein signaling RGS proteins VSMC phenotype blood pressure

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
11 07 2021
Historique:
received: 28 05 2021
revised: 25 06 2021
accepted: 07 07 2021
entrez: 7 8 2021
pubmed: 8 8 2021
medline: 27 10 2021
Statut: epublish

Résumé

The regulator of G-protein signaling 5 (RGS5) acts as an inhibitor of Gα

Identifiants

DOI: 10.3390/cells10071748 PMID: 34359918 PMC: PMC8306326
pubmed: 34359918
pii: cells10071748
doi: 10.3390/cells10071748
pmc: PMC8306326
pii:
doi:

Substances chimiques

RGS Proteins 0
Rgs5 protein, mouse 0
Mitogen-Activated Protein Kinase 1 EC 2.7.11.24
Mitogen-Activated Protein Kinase 3 EC 2.7.11.24
GTP-Binding Protein alpha Subunits, Gi-Go EC 3.6.5.1
rhoA GTP-Binding Protein EC 3.6.5.2
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Deutsche Forschungsgemeinschaft
ID : 394046768-SFB 1366-B5

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Auteurs

Eda Demirel (E)

Department of Cardiovascular Physiology, Institute of Physiology and Pathophysiology, Heidelberg University, 69120 Heidelberg, Germany.

Caroline Arnold (C)

Department of Cardiovascular Physiology, Institute of Physiology and Pathophysiology, Heidelberg University, 69120 Heidelberg, Germany.

Jaspal Garg (J)

Department of Cardiovascular Physiology, Institute of Physiology and Pathophysiology, Heidelberg University, 69120 Heidelberg, Germany.

Marius Andreas Jäger (MA)

Department of Cardiovascular Physiology, Institute of Physiology and Pathophysiology, Heidelberg University, 69120 Heidelberg, Germany.
ORCID: 0000-0003-0797-2673

Carsten Sticht (C)

NGS Core Facility, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.

Rui Li (R)

Department of Pharmacology, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany.

Hanna Kuk (H)

The Ottawa Department of Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.

Nina Wettschureck (N)

Department of Pharmacology, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany.

Markus Hecker (M)

Department of Cardiovascular Physiology, Institute of Physiology and Pathophysiology, Heidelberg University, 69120 Heidelberg, Germany.

Thomas Korff (T)

Department of Cardiovascular Physiology, Institute of Physiology and Pathophysiology, Heidelberg University, 69120 Heidelberg, Germany.
European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › RGS5 Attenuates Baseline Activity of ERK1/2...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Pression sanguine › RGS5 Attenuates Baseline Activity of ERK1/2...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › RGS5 Attenuates Baseline Activity of ERK1/2...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Cycle cellulaire › Points de contrôle du cycle cellulaire › RGS5 Attenuates Baseline Activity of ERK1/2...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › RGS5 Attenuates Baseline Activity of ERK1/2...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › RGS5 Attenuates Baseline Activity of ERK1/2...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Contraction musculaire › Contraction myocardique › Diastole › RGS5 Attenuates Baseline Activity of ERK1/2...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines G hétérotrimériques › Sous-unités alpha des protéines G › Sous-unités alpha Gi-Go des protéines G › RGS5 Attenuates Baseline Activity of ERK1/2...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › RGS5 Attenuates Baseline Activity of ERK1/2...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › RGS5 Attenuates Baseline Activity of ERK1/2...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Mitogen-Activated Protein Kinases › Extracellular Signal-Regulated MAP Kinases › Mitogen-Activated Protein Kinase 1 › RGS5 Attenuates Baseline Activity of ERK1/2...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Mitogen-Activated Protein Kinases › Extracellular Signal-Regulated MAP Kinases › Mitogen-Activated Protein Kinase 3 › RGS5 Attenuates Baseline Activity of ERK1/2...
questionsmedicales.fr › Tissus › Muscles › Muscles lisses › Muscles lisses vasculaires › RGS5 Attenuates Baseline Activity of ERK1/2...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes du muscle lisse › RGS5 Attenuates Baseline Activity of ERK1/2...
questionsmedicales.fr › Métabolisme › Phosphorylation › RGS5 Attenuates Baseline Activity of ERK1/2...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Régulateurs des protéines G › Protéines d'activation de la GTPase › Protéines RGS › RGS5 Attenuates Baseline Activity of ERK1/2...
questionsmedicales.fr › Cellules › Cellules cultivées › Sphéroïdes de cellules › RGS5 Attenuates Baseline Activity of ERK1/2...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Contraction musculaire › Contraction myocardique › Systole › RGS5 Attenuates Baseline Activity of ERK1/2...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Protéines G monomériques › Protéines G rho › Protéine G RhoA › RGS5 Attenuates Baseline Activity of ERK1/2...