Changes in Chromatin Organization Eradicate Cellular Stress Resilience to UVA/B Light and Induce Premature Aging.
Cell Cycle
/ radiation effects
Cellular Senescence
/ radiation effects
Chromatin
/ metabolism
Dose-Response Relationship, Radiation
Gene Expression Profiling
Gene Expression Regulation, Fungal
/ radiation effects
Histones
/ metabolism
Mutation
/ genetics
Saccharomyces cerevisiae
/ cytology
Saccharomyces cerevisiae Proteins
/ genetics
Stress, Physiological
/ genetics
Time Factors
Ultraviolet Rays
Saccharomyces cerevisiae
UVA-B irradiation
actin-related protein 4
aging
chromatin
chronological aging
linker histone
stress resilience
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
11 07 2021
11 07 2021
Historique:
received:
12
05
2021
revised:
10
06
2021
accepted:
08
07
2021
entrez:
7
8
2021
pubmed:
8
8
2021
medline:
27
10
2021
Statut:
epublish
Résumé
Complex interactions among DNA and nuclear proteins maintain genome organization and stability. The nuclear proteins, particularly the histones, organize, compact, and preserve the stability of DNA, but also allow its dynamic reorganization whenever the nuclear processes require access to it. Five histone classes exist and they are evolutionarily conserved among eukaryotes. The linker histones are the fifth class and over time, their role in chromatin has been neglected. Linker histones interact with DNA and the other histones and thus sustain genome stability and nuclear organization.
Identifiants
pubmed: 34359924
pii: cells10071755
doi: 10.3390/cells10071755
pmc: PMC8304177
pii:
doi:
Substances chimiques
Chromatin
0
Histones
0
Saccharomyces cerevisiae Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Bulgarian National Science Fund
ID : DN 11/15
Références
Nucleic Acids Res. 2001 May 15;29(10):2020-5
pubmed: 11353070
Trends Biochem Sci. 1996 Aug;21(8):287-8
pubmed: 8772381
Front Genet. 2016 Sep 27;7:177
pubmed: 27729926
Nucleic Acids Res. 2002 Apr 15;30(8):1743-50
pubmed: 11937627
Oxid Med Cell Longev. 2017;2017:2916985
pubmed: 28593023
Methods Mol Biol. 2004;241:77-91
pubmed: 14970647
Gene. 2007 Aug 1;397(1-2):84-93
pubmed: 17544228
Mol Microbiol. 1996 Mar;19(6):1159-66
pubmed: 8730858
DNA Repair (Amst). 2010 Sep 4;9(9):976-84
pubmed: 20674516
Int J Mol Sci. 2020 Jul 02;21(13):
pubmed: 32630624
Mech Ageing Dev. 2011 Jun-Jul;132(6-7):315-23
pubmed: 21736893
Curr Biol. 2004 Jul 27;14(14):R546-51
pubmed: 15268870
Mech Ageing Dev. 2019 Jan;177:55-65
pubmed: 30025887
Mech Ageing Dev. 2000 Dec 1;120(1-3):1-22
pubmed: 11087900
Am J Clin Dermatol. 2009;10 Suppl 1:19-24
pubmed: 19209950
Nature. 2010 Mar 25;464(7288):513-9
pubmed: 20336133
Curr Aging Sci. 2010 Jul;3(2):81-9
pubmed: 20044904
Int J Biochem Cell Biol. 2015 Feb;59:182-92
pubmed: 25542182
Am J Med Genet A. 2006 Dec 1;140(23):2603-24
pubmed: 16838330
BMC Syst Biol. 2015 Dec 29;9:96
pubmed: 26714768
Front Oncol. 2012 Dec 31;2:203
pubmed: 23293770
Mol Biol Cell. 2015 Dec 15;26(25):4524-31
pubmed: 26668170
FEBS Lett. 2011 Jul 7;585(13):2041-8
pubmed: 21081125
Cell. 2017 Feb 9;168(4):644-656
pubmed: 28187286
Nat Struct Mol Biol. 2013 Mar;20(3):290-9
pubmed: 23463314
Ann N Y Acad Sci. 2007 Apr;1100:60-74
pubmed: 17460165
Int J Mol Sci. 2018 Mar 15;19(3):
pubmed: 29543708
Br J Surg. 2016 Jan;103(2):e29-46
pubmed: 26771470
Int J Mol Sci. 2020 Dec 14;21(24):
pubmed: 33327536
Mol Cell Biol. 1997 May;17(5):2723-34
pubmed: 9111343
Subcell Biochem. 2012;57:145-59
pubmed: 22094421
Mol Cell. 2003 Jun;11(6):1685-92
pubmed: 12820979
Int J Mol Sci. 2011;12(11):8063-85
pubmed: 22174650
Nat Rev Mol Cell Biol. 2007 Sep;8(9):692-702
pubmed: 17700626
Cell. 2016 May 19;165(5):1197-1208
pubmed: 27133166
J Cell Biol. 2006 Jul 3;174(1):89-100
pubmed: 16818721
Cells. 2019 Jan 15;8(1):
pubmed: 30650660
Cell Metab. 2012 Jul 3;16(1):18-31
pubmed: 22768836
Stem Cells Int. 2016;2016:7370642
pubmed: 27148370
Cell Cycle. 2018;17(9):1035-1036
pubmed: 29895227
Nat Rev Mol Cell Biol. 2018 Mar;19(3):192-206
pubmed: 29018282
Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13765-70
pubmed: 16954188
Mol Aspects Med. 1994;15(1):1-77
pubmed: 7934671
Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):E41-9
pubmed: 23169651
Cells. 2019 Jul 01;8(7):
pubmed: 31266244
Int J Mol Sci. 2021 Jan 08;22(2):
pubmed: 33435578
Mol Cell. 2010 Oct 22;40(2):333-44
pubmed: 20965426
Biochim Biophys Acta. 2012 May;1819(5):366-74
pubmed: 22200500
Oxid Med Cell Longev. 2013;2013:437146
pubmed: 24023978
J Cell Biol. 2006 Dec 18;175(6):869-80
pubmed: 17158953
J Cell Biochem. 2008 May 1;104(1):59-67
pubmed: 18004728
Subcell Biochem. 2012;57:101-21
pubmed: 22094419
Exp Gerontol. 1997 Jul-Oct;32(4-5):383-94
pubmed: 9315443
Cells. 2020 May 25;9(5):
pubmed: 32466347
Nature. 2003 Jan 23;421(6921):436-40
pubmed: 12540918