The Role of P-Selectin in COVID-19 Coagulopathy: An Updated Review.
COVID-19
P-selectin
SARS-CoV-2
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
26 Jul 2021
26 Jul 2021
Historique:
received:
28
06
2021
revised:
20
07
2021
accepted:
21
07
2021
entrez:
7
8
2021
pubmed:
8
8
2021
medline:
26
8
2021
Statut:
epublish
Résumé
In severe COVID-19, which is characterized by blood clots and neutrophil-platelet aggregates in the circulating blood and different tissues, an increased incidence of cardiovascular complications and venous thrombotic events has been reported. The inflammatory storm that characterizes severe infections may act as a driver capable of profoundly disrupting the complex interplay between platelets, endothelium, and leukocytes, thus contributing to the definition of COVID-19-associated coagulopathy. In this frame, P-selectin represents a key molecule expressed on endothelial cells and on activated platelets, and contributes to endothelial activation, leucocyte recruitment, rolling, and tissue migration. Briefly, we describe the current state of knowledge about P-selectin involvement in COVID-19 pathogenesis, its possible use as a severity marker and as a target for host-directed therapeutic intervention.
Identifiants
pubmed: 34360707
pii: ijms22157942
doi: 10.3390/ijms22157942
pmc: PMC8348106
pii:
doi:
Substances chimiques
P-Selectin
0
SELP protein, human
0
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Italian Ministry of Health
ID : Linea 1 Ricerca Corrente, COVID-2020-12371817, COVID-2020-12371735.
Références
Cell Death Dis. 2021 Jan 5;12(1):50
pubmed: 33414384
Stroke Vasc Neurol. 2021 Mar;6(1):103-108
pubmed: 32973115
Int J Mol Sci. 2020 Jul 21;21(14):
pubmed: 32708334
Int J Mol Sci. 2020 Nov 03;21(21):
pubmed: 33153161
Life Sci. 2021 Jul 15;277:119634
pubmed: 34015287
Thromb Haemost. 2021 May 13;:
pubmed: 33984869
Blood. 2020 Sep 10;136(11):1317-1329
pubmed: 32573711
PLoS Biol. 2021 Feb 17;19(2):e3001109
pubmed: 33596198
Open Forum Infect Dis. 2017 Jan 19;4(1):ofw278
pubmed: 28480270
J Infect Dis. 2021 Mar 29;223(6):933-944
pubmed: 33280009
Int J Environ Res Public Health. 2020 Jan 01;17(1):
pubmed: 31906326
Blood. 2010 Dec 9;116(24):5377-82
pubmed: 20829374
Nat Rev Dis Primers. 2018 Mar 15;4:18010
pubmed: 29542687
Nat Rev Immunol. 2021 May;21(5):319-329
pubmed: 33824483
Nat Rev Drug Discov. 2021 Mar;20(3):217-243
pubmed: 33462432
Platelets. 2021 May 17;:1-11
pubmed: 33999778
HIV Med. 2015 Nov;16(10):608-19
pubmed: 26111187
Int Arch Allergy Immunol. 2020;181(11):879-887
pubmed: 32777786
Lancet Haematol. 2020 Aug;7(8):e575-e582
pubmed: 32619411
Eur Arch Otorhinolaryngol. 2021 May 5;:
pubmed: 33950356
Inflamm Res. 2017 Apr;66(4):283-302
pubmed: 27744631
Molecules. 2020 Jun 19;25(12):
pubmed: 32575485
J Hematol Oncol. 2018 Oct 11;11(1):125
pubmed: 30305116
Int J Mol Sci. 2020 Jan 17;21(2):
pubmed: 31963572
Vasc Med. 2021 May 13;:1358863X211007933
pubmed: 33985385
Mediterr J Hematol Infect Dis. 2021 Mar 01;13(1):e2021016
pubmed: 33747397
Lung. 2020 Feb;198(1):173-179
pubmed: 31897593
J Pain Res. 2021 Mar 30;14:849-856
pubmed: 33833562
J Immunol. 2006 Nov 15;177(10):7266-74
pubmed: 17082645
Arterioscler Thromb Vasc Biol. 2005 May;25(5):877-8
pubmed: 15863716
Atherosclerosis. 2021 Jun;327:87-99
pubmed: 34020784
Front Med (Lausanne). 2021 Apr 22;8:650129
pubmed: 33968958
JACC Basic Transl Sci. 2021 Mar;6(3):202-218
pubmed: 33649738
Cytometry B Clin Cytom. 2018 Mar;94(2):334-341
pubmed: 28052584
Oncotarget. 2015 Mar 30;6(9):6584-96
pubmed: 25762641
Blood. 2020 Sep 10;136(11):1330-1341
pubmed: 32678428
Thromb Res. 2014 Jan;133(1):17-24
pubmed: 24012101
Crit Care Explor. 2020 Aug 24;2(9):e0194
pubmed: 32904031
J Thromb Haemost. 2005 Aug;3(8):1590-6
pubmed: 16102023
Nat Rev Cardiol. 2021 May 6;:
pubmed: 33958774
Trends Mol Med. 2004 Apr;10(4):171-8
pubmed: 15059608
BMC Cardiovasc Disord. 2020 Aug 24;20(1):387
pubmed: 32831023
Anesth Analg. 2021 Apr 1;132(4):930-941
pubmed: 33093359
J Hematol Oncol. 2021 Apr 29;14(1):72
pubmed: 33926500
Ann Med. 2020 Sep;52(6):310-320
pubmed: 32634035
Cells. 2021 Jan 19;10(1):
pubmed: 33477776
Transl Res. 2021 Jan;227:89-99
pubmed: 32693031
Platelets. 2018 Nov;29(7):677-685
pubmed: 29461910
Arterioscler Thromb Vasc Biol. 2020 Dec;40(12):2975-2989
pubmed: 33052054
Biomed Res Int. 2017;2017:6138145
pubmed: 28680883
Mediterr J Hematol Infect Dis. 2011;3(1):e2011030
pubmed: 21869916
BMC Med. 2020 Nov 18;18(1):357
pubmed: 33203400
Nat Rev Cardiol. 2021 Mar;18(3):194-209
pubmed: 33214651
Braz J Med Biol Res. 2015 Feb;48(2):167-73
pubmed: 25466164
Front Endocrinol (Lausanne). 2021 Mar 30;12:651009
pubmed: 33859620
JAMA. 2021 Apr 27;325(16):1620-1630
pubmed: 33734299
J Int Med Res. 2020 Jun;48(6):300060519896437
pubmed: 32588673
Thromb Res. 2020 Jan;185:33-42
pubmed: 31756573
Front Oncol. 2021 Mar 15;11:642761
pubmed: 33791226
Acta Pharm Sin B. 2020 Jul;10(7):1205-1215
pubmed: 32318327
Lancet. 2009 May 30;373(9678):1849-60
pubmed: 19482214
J Thromb Haemost. 2014 Oct;12(10):1601-9
pubmed: 25088020
Crit Care. 2021 Feb 19;25(1):74
pubmed: 33608030
Drugs. 2020 Jan;80(1):79-84
pubmed: 31933169
Adv Ther. 2021 Jul;38(7):3911-3923
pubmed: 34086266
Nat Rev Cardiol. 2020 Sep;17(9):543-558
pubmed: 32690910
Circ Res. 2020 Sep 11;127(7):945-947
pubmed: 32757722
Platelets. 2021 May 19;32(4):560-567
pubmed: 33270471
Front Pharmacol. 2021 Apr 20;12:656244
pubmed: 33959024