Bioactive Compounds from Lemon (
adipocytes
insulin resistance
lemon extract
polyphenols
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
21 Jul 2021
21 Jul 2021
Historique:
received:
23
06
2021
revised:
19
07
2021
accepted:
20
07
2021
entrez:
7
8
2021
pubmed:
8
8
2021
medline:
16
9
2021
Statut:
epublish
Résumé
The consumption of plant-based food is important for health promotion, especially regarding the prevention and management of chronic diseases such as diabetes. We investigated the effects of a lemon extract (LE), containing ≥20.0% total flavanones and ≥1.0% total hydroxycinnamic acids, on insulin signaling in murine 3T3-L1 adipocytes treated with TNF-α, which was used to mimic in vitro the insulin resistance condition that characterizes diabetes mellitus. Our results showed LE increased PPARγ, GLUT4 and DGAT-1 levels, demonstrating the potential of this lemon extract in the management of insulin resistance conditions associated with TNF-α pathway activation. LE treatment further decreased the release of interleukin 6 (IL-6) and restored triglyceride synthesis, which is the main feature of a healthy adipocyte.
Identifiants
pubmed: 34361563
pii: molecules26154411
doi: 10.3390/molecules26154411
pmc: PMC8347189
pii:
doi:
Substances chimiques
Phytochemicals
0
Plant Extracts
0
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
J Pharm Biomed Anal. 2010 Jan 20;51(2):327-45
pubmed: 19748198
Nat Biotechnol. 2014 Jul;32(7):656-62
pubmed: 24908277
Planta Med. 2015 Aug;81(12-13):975-94
pubmed: 26132858
Int J Mol Med. 2019 Oct;44(4):1523-1530
pubmed: 31364723
Innate Immun. 2012 Apr;18(2):231-40
pubmed: 21450790
Oxid Med Cell Longev. 2019 Mar 10;2019:5484138
pubmed: 30962863
Cytokine Growth Factor Rev. 2003 Oct;14(5):447-55
pubmed: 12948526
Nutr Metab (Lond). 2019 Jul 18;16:47
pubmed: 31346342
Nat Prod Res. 2020 Feb 3;:1-5
pubmed: 32009451
Mol Nutr Food Res. 2017 Dec;61(12):
pubmed: 28759152
Biochim Biophys Acta. 2005 Oct 15;1737(1):76-82
pubmed: 16214399
Front Microbiol. 2019 Apr 03;10:660
pubmed: 31001233
Int J Mol Sci. 2019 Apr 26;20(9):
pubmed: 31027340
Endocrine. 2004 Mar-Apr;23(2-3):177-82
pubmed: 15146098
Biochem Biophys Res Commun. 2008 Sep 26;374(3):405-8
pubmed: 18655773
Science. 1993 Jan 1;259(5091):87-91
pubmed: 7678183
Crit Rev Food Sci Nutr. 2017 Feb 11;57(3):613-631
pubmed: 25675136
Molecules. 2021 May 03;26(9):
pubmed: 34063700
Food Funct. 2021 Jun 8;12(11):4783-4796
pubmed: 34100500
Adipocyte. 2018;7(3):226-228
pubmed: 30001663
Nutrients. 2020 Sep 23;12(10):
pubmed: 32977511