Evidence from a meta-analysis for association of MC4R rs17782313 and FTO rs9939609 polymorphisms with susceptibility to obesity in children.

Alpha-Ketoglutarate-Dependent Dioxygenase FTO / genetics Child Genetic Predisposition to Disease Humans Pediatric Obesity / etiology Polymorphism, Single Nucleotide Prognosis Receptor, Melanocortin, Type 4 / genetics
Children Fat mass and obesity associated gene Melanocortin-4 receptor gene Obesity Polymorphism

Journal

Diabetes & metabolic syndrome
ISSN: 1878-0334
Titre abrégé: Diabetes Metab Syndr
Pays: Netherlands
ID NLM: 101462250

Informations de publication

Date de publication:
Historique:
received: 27 06 2021
revised: 24 07 2021
accepted: 26 07 2021
pubmed: 8 8 2021
medline: 27 1 2022
entrez: 7 8 2021
Statut: ppublish

Résumé

The aim of this study was to evaluate the association of MC4R rs17782313 and FTO rs9939609 polymorphisms with childhood obesity. A universal search was performed up to May 2021. A total of 31 studies including 13 studies with 9565 cases and 11956 controls on MC4R rs17782313 and 18 studies with 4789 cases and 15918 controls on FTO rs9939609 were selected. Pooled data showed that FTO rs9930506 and MC4R rs17782313 polymorphisms were significantly associated with obesity in children. Stratified analyses revealed that these genetic variants were associated with childhood obesity in Caucasian and Asian children.

Sections du résumé

BACKGROUND AND AIM OBJECTIVE
The aim of this study was to evaluate the association of MC4R rs17782313 and FTO rs9939609 polymorphisms with childhood obesity.
METHODS METHODS
A universal search was performed up to May 2021.
RESULTS RESULTS
A total of 31 studies including 13 studies with 9565 cases and 11956 controls on MC4R rs17782313 and 18 studies with 4789 cases and 15918 controls on FTO rs9939609 were selected.
CONCLUSIONS CONCLUSIONS
Pooled data showed that FTO rs9930506 and MC4R rs17782313 polymorphisms were significantly associated with obesity in children. Stratified analyses revealed that these genetic variants were associated with childhood obesity in Caucasian and Asian children.

Identifiants

DOI: 10.1016/j.dsx.2021.102234 PMID: 34364300
pubmed: 34364300
pii: S1871-4021(21)00254-X
doi: 10.1016/j.dsx.2021.102234
pii:
doi:

Substances chimiques

MC4R protein, human 0
Receptor, Melanocortin, Type 4 0
Alpha-Ketoglutarate-Dependent Dioxygenase FTO EC 1.14.11.33
FTO protein, human EC 1.14.11.33

Types de publication

Journal Article Meta-Analysis Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

102234

Informations de copyright

Copyright © 2021 Diabetes India. Published by Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no conflict of interest.

Auteurs

Seyed Alireza Dastgheib (SA)

Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Reza Bahrami (R)

Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: bahramir@sums.ac.ir.

Sepideh Setayesh (S)

School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Seyedali Salari (S)

Department of Biology, Science and Arts University, Yazd, Iran.

Seyed Reza Mirjalili (SR)

Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Mahmood Noorishadkam (M)

Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Jalal Sadeghizadeh-Yazdi (J)

Department of Food Science and Technology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Elahe Akbarian (E)

Children Growth Disorder Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Hossein Neamatzadeh (H)

Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Dioxygenases › AlkB enzymes › Alpha-ketoglutarate-dependent dioxygenase FTO › Evidence from a meta-analysis for association...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Evidence from a meta-analysis for association...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Evidence from a meta-analysis for association...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Evidence from a meta-analysis for association...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Obésité pédiatrique › Evidence from a meta-analysis for association...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Evidence from a meta-analysis for association...
questionsmedicales.fr › Diagnostic › Pronostic › Evidence from a meta-analysis for association...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur hormone hypophysaire › Récepteur corticotrophine › Récepteurs à la mélanocortine › Récepteur de la mélanocortine de type 4 › Evidence from a meta-analysis for association...