IFN-κ Is a Rheostat for Development of Psoriasiform Inflammation.

Animals CD4-Positive T-Lymphocytes / immunology CD8-Positive T-Lymphocytes / immunology Cytokines / genetics Disease Models, Animal Female Humans Imiquimod Inflammation / immunology Interferon Type I / genetics Male Mice Mice, Inbred C57BL Mice, Knockout Psoriasis / immunology Skin / immunology Up-Regulation

Journal

The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720

Informations de publication

Date de publication:
01 2022
Historique:
received: 18 02 2021
revised: 07 05 2021
accepted: 24 05 2021
pubmed: 9 8 2021
medline: 15 1 2022
entrez: 8 8 2021
Statut: ppublish

Résumé

Psoriasis is a common, inflammatory autoimmune skin disease. Early detection of an IFN-1 signature occurs in many psoriasis lesions, but the source of IFN production remains debated. IFN-κ is an important source of IFN-1 production in the epidermis. We identified a correlation between IFN-regulated and psoriasis-associated genes in human lesional skin. We thus wanted to explore the effects of IFN-κ in psoriasis using the well-characterized imiquimod psoriasis model. Three mouse strains aged 10 weeks were used: wild-type C57Bl/6, C57Bl/6 that overexpress Ifnk in the epidermis (i.e., transgenic), and total body Ifnk

Identifiants

DOI: 10.1016/j.jid.2021.05.029 PMID: 34364883 PMC: PMC8688309
pubmed: 34364883
pii: S0022-202X(21)01452-4
doi: 10.1016/j.jid.2021.05.029
pmc: PMC8688309
mid: NIHMS1731160
pii:
doi:

Substances chimiques

Cytokines 0
Interferon Type I 0
interferon kappa 0
Imiquimod P1QW714R7M

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

155-165.e3

Subventions

Organisme : NIAMS NIH HHS
ID : R01 AR073196
Pays : United States
Organisme : NIAMS NIH HHS
ID : F31 AR077988
Pays : United States
Organisme : NIAMS NIH HHS
ID : K08 AR060802
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR075043
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI130025
Pays : United States
Organisme : NIAMS NIH HHS
ID : P50 AR070590
Pays : United States
Organisme : NIAMS NIH HHS
ID : K24 AR076975
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR071384
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

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Auteurs

Mehrnaz Gharaee-Kermani (M)

Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA; Department of Dermatology, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA.

Shannon N Estadt (SN)

Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA; Graduate Program in Immunology, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA.

Lam C Tsoi (LC)

Department of Dermatology, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA; Department of Computational Medicine and Bioinformatics, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA.

Sonya J Wolf-Fortune (SJ)

Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA; Graduate Program in Immunology, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA.

Jianhua Liu (J)

Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA.

Xianying Xing (X)

Department of Dermatology, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA.

Jonathon Theros (J)

Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA.

Tamra J Reed (TJ)

Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA.

Lori Lowe (L)

Department of Dermatology, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA; Department of Pathology, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA.

Dennis Gruszka (D)

Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA; Department of Dermatology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.

Nicole L Ward (NL)

Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA; Department of Dermatology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.

Johann E Gudjonsson (JE)

Department of Dermatology, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA.

J Michelle Kahlenberg (JM)

Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA; Department of Dermatology, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA. Electronic address: mkahlenb@med.umich.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › IFN-κ Is a Rheostat for Development of...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › IFN-κ Is a Rheostat for Development of...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › IFN-κ Is a Rheostat for Development of...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › IFN-κ Is a Rheostat for Development of...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › IFN-κ Is a Rheostat for Development of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › IFN-κ Is a Rheostat for Development of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Aminoquinoléines › Imiquimod › IFN-κ Is a Rheostat for Development of...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › IFN-κ Is a Rheostat for Development of...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interférons › Interféron de type I › IFN-κ Is a Rheostat for Development of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › IFN-κ Is a Rheostat for Development of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › IFN-κ Is a Rheostat for Development of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › IFN-κ Is a Rheostat for Development of...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Dermatoses papulosquameuses › Psoriasis › IFN-κ Is a Rheostat for Development of...
questionsmedicales.fr › Système tégumentaire › Peau › IFN-κ Is a Rheostat for Development of...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation positive › IFN-κ Is a Rheostat for Development of...