Deletion of heterogeneous nuclear ribonucleoprotein F in renal tubules downregulates SGLT2 expression and attenuates hyperfiltration and kidney injury in a mouse model of diabetes.
Acute Kidney Injury
/ metabolism
Angiotensinogen
Animals
Blood Glucose
/ metabolism
Blood Pressure
Blotting, Western
Diabetes Mellitus, Type 1
/ metabolism
Disease Models, Animal
Down-Regulation
Glomerular Filtration Rate
/ physiology
Heterogeneous-Nuclear Ribonucleoprotein Group F-H
/ physiology
Kidney Tubules
/ metabolism
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Purinergic P1 Receptor Antagonists
/ pharmacology
Real-Time Polymerase Chain Reaction
Sodium-Glucose Transporter 2
/ metabolism
Theophylline
/ analogs & derivatives
Akita mice
Angiotensinogen
Heterogeneous nuclear ribonucleoprotein F
Sodium-glucose co-transporter 2
Type 1 diabetes
Journal
Diabetologia
ISSN: 1432-0428
Titre abrégé: Diabetologia
Pays: Germany
ID NLM: 0006777
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
11
02
2021
accepted:
26
05
2021
pubmed:
10
8
2021
medline:
26
3
2022
entrez:
9
8
2021
Statut:
ppublish
Résumé
We previously reported that renal tubule-specific deletion of heterogeneous nuclear ribonucleoprotein F (Hnrnpf) results in upregulation of renal angiotensinogen (Agt) and downregulation of sodium-glucose co-transporter 2 (Sglt2) in Hnrnpf Akita Hnrnpf Akita mice exhibited elevated systolic blood pressure as compared with Ctrl mice, which was significantly higher in Akita Hnrnpf The renoprotective effect of Sglt2 downregulation overcomes the renal injurious effect of Agt when these opposing factors coexist under diabetic conditions, at least partly via the activation of tubuloglomerular feedback.
Identifiants
pubmed: 34370045
doi: 10.1007/s00125-021-05538-9
pii: 10.1007/s00125-021-05538-9
pmc: PMC8992778
mid: NIHMS1792369
doi:
Substances chimiques
Agt protein, mouse
0
Blood Glucose
0
Heterogeneous-Nuclear Ribonucleoprotein Group F-H
0
Purinergic P1 Receptor Antagonists
0
Slc5a2 protein, mouse
0
Sodium-Glucose Transporter 2
0
Angiotensinogen
11002-13-4
8-cyclopentyl-1,3-dimethylxanthine
35873-49-5
Theophylline
C137DTR5RG
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2589-2601Subventions
Organisme : NCATS NIH HHS
ID : KL2 TR001882
Pays : United States
Organisme : CIHR
ID : PJT 173512
Pays : Canada
Organisme : CIHR
ID : MOP-84363
Pays : Canada
Organisme : CIHR
ID : MOP-142378
Pays : Canada
Organisme : CIHR
ID : MOP-97742
Pays : Canada
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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