Investigation of cardiac glycosides from oleander in a human induced pluripotent stem cells derived cardiomyocyte model.
Arrhythmia
Cardiac glycoside
Cardiotoxicity
Microelectrode array
Oleander poisoning
Journal
Toxicology letters
ISSN: 1879-3169
Titre abrégé: Toxicol Lett
Pays: Netherlands
ID NLM: 7709027
Informations de publication
Date de publication:
10 Oct 2021
10 Oct 2021
Historique:
received:
04
05
2021
revised:
13
07
2021
accepted:
27
07
2021
pubmed:
10
8
2021
medline:
21
9
2021
entrez:
9
8
2021
Statut:
ppublish
Résumé
The ingestion of Nerium oleander and Thevetia peruviana are common causes for poisoning in Southeast Asia. All parts of the oleander shrub contain cardiac glycosides of the cardenolide type. These glycosides act via inhibition of a Na
Identifiants
pubmed: 34371141
pii: S0378-4274(21)00200-9
doi: 10.1016/j.toxlet.2021.07.020
pii:
doi:
Substances chimiques
Cardenolides
0
Cardiac Glycosides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
261-266Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that there are no conflicts of interest. The study was funded by the German Ministry of Defence. However, the design, performance, data interpretation and manuscript writing was under the control of the authors and has not been influenced by the German Ministry of Defence.