H Thiermann

Affiliations

Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstraße 11, 80937, München, Germany.

Publications (60)

Comparison of the toxicity of sulfur mustard and its oxidation products in vitro.

Toxicology letters

Avec: Amelie Tsoutsoulopoulos , Sabrina Brockmöller , Horst Thiermann , Dirk Steinritz

Sulfur mustard alkylates steroid hormones and impacts hormone function in vitro.

Archives of toxicology

Avec: Robin Lüling , Helena Singer , Tanja Popp , Harald John , Ingrid Boekhoff , Horst Thiermann , Lena J Daumann , Konstantin Karaghiosoff , Thomas Gudermann , Dirk Steinritz

Necrosulfonamide - Unexpected effect in the course of a sulfur mustard intoxication.

Chemico-biological interactions

Avec: Georg Menacher , Frank Balszuweit , Simon Lang , Horst Thiermann , Kai Kehe , Thomas Gudermann , Annette Schmidt , Dirk Steinritz , Tanja Popp

Transthyretin as a target of alkylation and a potential biomarker for sulfur mustard poisoning: Electrophoretic and mass spectrometric identification and characterization.

Drug testing and analysis

Avec: Wolfgang Schmeißer , Robin Lüling , Dirk Steinritz , Horst Thiermann , Theo Rein , Harald John

The Efficiency of Direct Maturation: the Comparison of Two hiPSC Differentiation Approaches into Motor Neurons.

Stem cells international

Avec: Catherine Schaefers , Simone Rothmiller , Horst Thiermann , Theo Rein , Annette Schmidt

Effect of sulfur mustard on melanogenesis in vitro.

Toxicology letters

Avec: Katharina Müller-Dott , Horst Thiermann , Dirk Steinritz , Tanja Popp

Forensic evidence of sulfur mustard exposure in real cases of human poisoning by detection of diverse albumin-derived protein adducts.

Archives of toxicology

Avec: Harald John , Marianne Koller , Franz Worek , Horst Thiermann , Markus Siegert

Human small bowel as model for poisoning with organophosphorus compounds.

Toxicology in vitro : an international journal published in association with BIBRA

Avec: Katharina Marquart , Olga Prokopchuk , Dirk Wilhelm , Franz Worek , Horst Thiermann , Marc E Martignoni , Timo Wille

New Resensitizers for the Nicotinic Acetylcholine Receptor by Ligand-Based Pharmacophore Modeling.

Current computer-aided drug design

Avec: Thomas Wein , Klaus T Wanner , Sebastian Rappenglück , Sonja Sichler , Karin V Niessen , Thomas Seeger , Franz Worek , Horst Thiermann

A novel high-performance liquid chromatography with diode array detector method for the simultaneous quantification of the enzyme-reactivating oximes obidoxime, pralidoxime, and HI-6 in human plasma.

Drug testing and analysis

Avec: Tamara Kranawetvogl , Dirk Steinritz , Horst Thiermann , Harald John

Assessment of α-amanitin toxicity and effects of silibinin and penicillin in different in vitro models.

Toxicology in vitro : an international journal published in association with BIBRA

Avec: Tanja Popp , Frank Balszuweit , Annette Schmidt , Florian Eyer , Horst Thiermann , Dirk Steinritz

Alkylated albumin-derived dipeptide C(-HETE)P derivatized by propionic anhydride as a biomarker for the verification of poisoning with sulfur mustard.

Analytical and bioanalytical chemistry

Avec: Annika Richter , Markus Siegert , Horst Thiermann , Harald John

Alkylated epidermal creatine kinase as a biomarker for sulfur mustard exposure: comparison to adducts of albumin and DNA in an in vivo rat study.

Archives of toxicology

Avec: Dirk Steinritz , Robin Lüling , Markus Siegert , Julia Herbert , Harald Mückter , Christian D Taeger , Thomas Gudermann , Alexander Dietrich , Horst Thiermann , Harald John

Release of protein-bound nerve agents by excess fluoride from whole blood: GC-MS/MS method development, validation, and application to a real-life denatured blood sample.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Avec: Marianne Koller , Horst Thiermann , Franz Worek , Timo Wille

Evidence of nerve agent VX exposure in rat plasma by detection of albumin-adducts in vitro and in vivo.

Archives of toxicology

Avec: Tamara Kranawetvogl , Andreas Kranawetvogl , Lisa Scheidegger , Timo Wille , Dirk Steinritz , Franz Worek , Horst Thiermann , Harald John

[Chemical warfare agent poisoning].

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz

Avec: Timo Wille , Dirk Steinritz , Franz Worek , Horst Thiermann

Validation of the CULTEX® Radial Flow System for the assessment of the acute inhalation toxicity of airborne particles.

Toxicology in vitro : an international journal published in association with BIBRA

Avec: Amelie Tsoutsoulopoulos , Katrin Gohlsch , Niklas Möhle , Andreas Breit , Sebastian Hoffmann , Olaf Krischenowski , Harald Mückter , Thomas Gudermann , Horst Thiermann , Michaela Aufderheide , Dirk Steinritz

Collision-induced mass spectrometric fragmentation of protonated dimethoate and omethoate generated by electrospray ionization.

Rapid communications in mass spectrometry : RCM

Avec: Harald John , Markus Siegert , Andreas Kranawetvogl , Horst Thiermann

A case report of cholinesterase inhibitor poisoning: cholinesterase activities and analytical methods for diagnosis and clinical decision making.

Archives of toxicology

Avec: N Amend , J Langgartner , M Siegert , T Kranawetvogl , M Koller , H John , C Pflügler , C Mögele-Schmid , F Worek , H Thiermann , T Wille

Catalytic activity and stereoselectivity of engineered phosphotriesterases towards structurally different nerve agents in vitro.

Archives of toxicology

Avec: Anja Köhler , Benjamin Escher , Laura Job , Marianne Koller , Horst Thiermann , Arne Skerra , Franz Worek

Evidence of sulfur mustard poisoning by detection of the albumin-derived dipeptide biomarker C(-HETE)P after nicotinylation.

Drug testing and analysis

Avec: Harald John , Annika Richter , Horst Thiermann

Organophosphorus pesticides exhibit compound specific effects in rat precision-cut lung slices (PCLS): mechanisms involved in airway response, cytotoxicity, inflammatory activation and antioxidative defense.

Archives of toxicology

Avec: Jonas Tigges , Franz Worek , Horst Thiermann , Timo Wille

Nontargeted High-Resolution Mass Spectrometric Workflow for the Detection of Butyrylcholinesterase-Derived Adducts with Organophosphorus Toxicants and Structural Characterization of Their Phosphyl Moiety after In-Source Fragmentation.

Analytical chemistry

Avec: Harald John , Marina Dentzel , Markus Siegert , Horst Thiermann

A novel binding site in the nicotinic acetylcholine receptor for MB327 can explain its allosteric modulation relevant for organophosphorus-poisoning treatment.

Toxicology letters

Avec: Jesko Kaiser , Christoph G W Gertzen , Tamara Bernauer , Georg Höfner , Karin V Niessen , Thomas Seeger , Franz F Paintner , Klaus T Wanner , Franz Worek , Horst Thiermann , Holger Gohlke

Isolation of human TRPA1 channel from transfected HEK293 cells and identification of alkylation sites after sulfur mustard exposure.

Archives of toxicology

Avec: Katharina Müller-Dott , Horst Thiermann , Harald John , Dirk Steinritz

Phosphonylated tyrosine and lysine residues as biomarkers of local exposure of human hair to the organophosphorus nerve agents sarin and VX.

Drug testing and analysis

Avec: Harald John , Tamara Lindl , Henrik Reuter , Wolfgang Schmeißer , Michael Schrader , Horst Thiermann

The blistering warfare agent O-mustard (agent T) generates protein-adducts with human serum albumin useful for biomedical verification of exposure and forms intramolecular cross-links.

Analytical and bioanalytical chemistry

Avec: Marc-Michael Blum , Wolfgang Schmeißer , Marina Dentzel , Horst Thiermann , Harald John

In Vitro Interaction of Organophosphono- and Organophosphorothioates with Human Acetylcholinesterase.

Molecules (Basel, Switzerland)

Avec: Franz Worek , Horst Thiermann , Marianne Koller , Timo Wille

Organophosphorus compounds and oximes: a critical review.

Archives of toxicology

Avec: Franz Worek , Horst Thiermann , Timo Wille

Identification of creatine kinase and alpha-1 antitrypsin as protein targets of alkylation by sulfur mustard.

Drug testing and analysis

Avec: Robin Lüling , Wolfgang Schmeißer , Markus Siegert , Harald Mückter , Alexander Dietrich , Horst Thiermann , Thomas Gudermann , Harald John , Dirk Steinritz

A novel exposure system generating nebulized aerosol of sulfur mustard in comparison to the standard submerse exposure.

Chemico-biological interactions

Avec: Amelie Tsoutsoulopoulos , Markus Siegert , Harald John , Tabea Zubel , Aswin Mangerich , Annette Schmidt , Harald Mückter , Thomas Gudermann , Horst Thiermann , Dirk Steinritz , Tanja Popp

Methionine

Drug testing and analysis

Avec: Markus Siegert , Felix Gandor , Andreas Kranawetvogl , Hans Börner , Horst Thiermann , Harald John

Alkylation of rabbit muscle creatine kinase surface methionine residues inhibits enzyme activity in vitro.

Archives of toxicology

Avec: Dirk Steinritz , Robin Lüling , Markus Siegert , Harald Mückter , Tanja Popp , Peter Reinemer , Thomas Gudermann , Horst Thiermann , Harald John

Early diagnosis of nerve agent exposure with a mobile test kit and implications for medical countermeasures: a trigger to react.

BMJ military health

Avec: Timo Wille , Snezana Djordjević , Franz Worek , Horst Thiermann , Slavica Vučinić

Assessment of the Acute Inhalation Toxicity of Airborne Particles by Exposing Cultivated Human Lung Cells at the Air-Liquid Interface.

Journal of visualized experiments : JoVE

Pro: Oximes should be used routinely in organophosphate poisoning.

British journal of clinical pharmacology

Avec: Horst Thiermann , Franz Worek

Highly stable peptide adducts from hard keratins as biomarkers to verify local sulfur mustard exposure of hair by high-resolution mass spectrometry.

Archives of toxicology

Avec: Wolfgang Schmeißer , Markus Siegert , Horst Thiermann , Theo Rein , Harald John

The phosphylated butyrylcholinesterase-derived tetrapeptide GlyGluSerAla proves exposure to organophosphorus agents with enantioselectivity.

Archives of toxicology

Avec: Tamara Kranawetvogl , Markus Siegert , Dirk Steinritz , Horst Thiermann , Harald John

Activation of the human TRPA1 channel by different alkylating sulfur and nitrogen mustards and structurally related chemotherapeutic drugs.

Toxicology letters

Avec: Katharina Müller-Dott , Sarah Christine Raßmuß , Marc-Michael Blum , Horst Thiermann , Harald John , Dirk Steinritz

The Clinical Toxicology Recommendations Collaborative: purpose, organization, and methodology.

Clinical toxicology (Philadelphia, Pa.)

Avec: Martin F Wilks , Christopher Hoyte , Kirk L Cumpston , Hossein Hassanian-Moghaddam , Man-Li Tse , Ana Ferrer-Dufol , Horst Thiermann

Diagnostics and treatment of nerve agent poisoning-current status and future developments.

Annals of the New York Academy of Sciences

Avec: Niko Amend , Karin V Niessen , Thomas Seeger , Timo Wille , Franz Worek , Horst Thiermann

Validation of automated pipetting systems for cell culture seeding, exposure and bio-analytical assays in sulfur mustard toxicology.

Toxicology letters

Avec: Simone Rothmiller , Frank Balszuweit , Georg Menacher , Dirk Steinritz , Kai Kehe , Horst Thiermann , Annette Schmidt

Impact of soman and acetylcholine on the effects of propofol in cultured cortical networks.

Toxicology letters

Avec: Berthold Drexler , Thomas Seeger , Franz Worek , Horst Thiermann , Bernd Antkowiak , Christian Grasshoff

Screening of chiral shift reagents suitable to generically separate the enantiomers of V-agents by

Toxicology letters

Avec: Marianne Koller , Horst Thiermann , Franz Worek

Skin sensitizing effects of sulfur mustard and other alkylating agents in accordance to OECD guidelines.

Toxicology letters

Avec: Dirk Steinritz , Simon Lang , Tanja Popp , Markus Siegert , Simone Rothmiller , Andreas Kranawetvogl , Annette Schmidt , Harald John , Thomas Gudermann , Horst Thiermann , Kai Kehe

The arrhythmogenic potential of nerve agents and a cardiac safety profile of antidotes - A proof-of-concept study using human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CM).

Toxicology letters

Avec: Niko Amend , Horst Thiermann , Franz Worek , Timo Wille

Effect of cholinergic crisis on the potency of different emergency anaesthesia protocols in soman-poisoned rats.

Clinical toxicology (Philadelphia, Pa.)

Avec: Katharina Marquart , Julia Herbert , Niko Amend , Horst Thiermann , Franz Worek , Timo Wille

Evaluation of selective and non-selective cyclooxygenase inhibitors on sulfur mustard-induced pro-inflammatory cytokine formation in normal human epidermal keratinocytes.

Toxicology letters

Avec: Simon Wagner , Simon Lang , Tanja Popp , Annette Schmidt , Horst Thiermann , Dirk Steinritz , Kai Kehe

Adduct of the blistering warfare agent sesquimustard with human serum albumin and its mass spectrometric identification for biomedical verification of exposure.

Analytical and bioanalytical chemistry

Avec: Marc-Michael Blum , Annika Richter , Markus Siegert , Horst Thiermann , Harald John

Chronic senescent human mesenchymal stem cells as possible contributor to the wound healing disorder after exposure to the alkylating agent sulfur mustard.

Archives of toxicology

Avec: Simone Rothmiller , Niklas Jäger , Nicole Meier , Thimo Meyer , Adrian Neu , Dirk Steinritz , Horst Thiermann , Michael Scherer , Christoph Rummel , Aswin Mangerich , Alexander Bürkle , Annette Schmidt

Genomic Adaption and Mutational Patterns in a HaCaT Subline Resistant to Alkylating Agents and Ionizing Radiation.

International journal of molecular sciences

Avec: Reinhard Ullmann , Benjamin Valentin Becker , Simone Rothmiller , Annette Schmidt , Horst Thiermann , Hanns Leonhard Kaatsch , Gerrit Schrock , Jessica Müller , Julia Jakobi , Richard Obermair , Matthias Port , Harry Scherthan

Optimization of long-term cold storage of rat precision-cut lung slices with a tissue preservation solution.

American journal of physiology. Lung cellular and molecular physiology

Avec: Jonas Tigges , Florian Eggerbauer , Franz Worek , Horst Thiermann , Ursula Rauen , Timo Wille

Poisoning by organophosphorus nerve agents and pesticides: An overview of the principle strategies and current progress of mass spectrometry-based procedures for verification.

Journal of mass spectrometry and advances in the clinical lab

Avec: Harald John , Horst Thiermann

Evidence of exposure to organophosphorus toxicants by detection of the propionylated butyrylcholinesterase-derived nonapeptide-adduct as a novel biomarker.

Forensic science international

Avec: Harald John , Annika Richter , Markus Siegert , Florian Eyer , Horst Thiermann

Investigation of cardiac glycosides from oleander in a human induced pluripotent stem cells derived cardiomyocyte model.

Toxicology letters

Avec: N Amend , F Worek , H Thiermann , T Wille

Post-VX exposure treatment of rats with engineered phosphotriesterases.

Archives of toxicology

Avec: Lisa Stigler , Anja Köhler , Marianne Koller , Laura Job , Benjamin Escher , Heidrun Potschka , Horst Thiermann , Arne Skerra , Franz Worek , Timo Wille

Alkylated glutamic acid and histidine derived from protein-adducts indicate exposure to sulfur mustard in avian serum.

Drug testing and analysis

Avec: Harald John , Philipp Hörmann , Michael Schrader , Horst Thiermann

Sulfur mustard single-dose exposure triggers senescence in primary human dermal fibroblasts.

Archives of toxicology

Avec: Gabriele Horn , Catherine Schäfers , Horst Thiermann , Sandra Völkl , Annette Schmidt , Simone Rothmiller

A pharmacologically pre-contracted smooth muscle bowel model for the study of highly-potent opioid receptor agonists and antagonists.

Toxicology letters

Avec: Niko Amend , Horst Thiermann , Franz Worek , Timo Wille

Targeting miR-497-5p rescues human keratinocyte dysfunction upon skin exposure to sulfur mustard.

Cell death & disease

Avec: Virginia Egea , Karina Lutterberg , Dirk Steinritz , Simone Rothmiller , Konrad Steinestel , Jan Caca , Andreas Nerlich , Helmut Blum , Sarah Reschke , Sajjad Khani , Alexander Bartelt , Franz Worek , Horst Thiermann , Christian Weber , Christian Ries

Réseau de co-auteurs

Horst Thiermann 58 collaborations

Harald John 25 collaborations

Dirk Steinritz 23 collaborations

Franz Worek 22 collaborations

Markus Siegert 14 collaborations

Timo Wille 14 collaborations

Annette Schmidt 10 collaborations

Thomas Gudermann 9 collaborations

Tanja Popp 8 collaborations

Simone Rothmiller 7 collaborations

Marianne Koller 6 collaborations

Harald Mückter 6 collaborations

Robin Lüling 5 collaborations

Wolfgang Schmeißer 5 collaborations

Amelie Tsoutsoulopoulos 4 collaborations

Kai Kehe 4 collaborations

Thomas Seeger 4 collaborations

Annika Richter 4 collaborations

Andreas Kranawetvogl 4 collaborations

Niko Amend 4 collaborations

Frank Balszuweit 3 collaborations

Simon Lang 3 collaborations

Theo Rein 3 collaborations

Katharina Müller-Dott 3 collaborations

Karin V Niessen 3 collaborations

Tamara Kranawetvogl 3 collaborations

Marc-Michael Blum 3 collaborations

Georg Menacher 2 collaborations

Katharina Marquart 2 collaborations

Klaus T Wanner 2 collaborations

Florian Eyer 2 collaborations

Julia Herbert 2 collaborations

Alexander Dietrich 2 collaborations

Katrin Gohlsch 2 collaborations

Niklas Möhle 2 collaborations

Andreas Breit 2 collaborations

Sebastian Hoffmann 2 collaborations

Olaf Krischenowski 2 collaborations

Michaela Aufderheide 2 collaborations

N Amend 2 collaborations

F Worek 2 collaborations

T Wille 2 collaborations

Anja Köhler 2 collaborations

Benjamin Escher 2 collaborations

Laura Job 2 collaborations

Arne Skerra 2 collaborations

Jonas Tigges 2 collaborations

Marina Dentzel 2 collaborations

Michael Schrader 2 collaborations

Aswin Mangerich 2 collaborations

Sabrina Brockmöller 1 collaboration

Helena Singer 1 collaboration

Ingrid Boekhoff 1 collaboration

Lena J Daumann 1 collaboration

Konstantin Karaghiosoff 1 collaboration

Catherine Schaefers 1 collaboration

Olga Prokopchuk 1 collaboration

Dirk Wilhelm 1 collaboration

Marc E Martignoni 1 collaboration

Thomas Wein 1 collaboration

Sebastian Rappenglück 1 collaboration

Sonja Sichler 1 collaboration

Christian D Taeger 1 collaboration

Lisa Scheidegger 1 collaboration

J Langgartner 1 collaboration

M Siegert 1 collaboration

T Kranawetvogl 1 collaboration

M Koller 1 collaboration

H John 1 collaboration

C Pflügler 1 collaboration

C Mögele-Schmid 1 collaboration

Jesko Kaiser 1 collaboration

Christoph G W Gertzen 1 collaboration

Tamara Bernauer 1 collaboration

Georg Höfner 1 collaboration

Franz F Paintner 1 collaboration

Holger Gohlke 1 collaboration

Tamara Lindl 1 collaboration

Henrik Reuter 1 collaboration

Tabea Zubel 1 collaboration

Felix Gandor 1 collaboration

Hans Börner 1 collaboration

Peter Reinemer 1 collaboration

Snezana Djordjević 1 collaboration

Slavica Vučinić 1 collaboration

Sarah Christine Raßmuß 1 collaboration

Martin F Wilks 1 collaboration

Christopher Hoyte 1 collaboration

Kirk L Cumpston 1 collaboration

Hossein Hassanian-Moghaddam 1 collaboration

Man-Li Tse 1 collaboration

Ana Ferrer-Dufol 1 collaboration

Berthold Drexler 1 collaboration

Bernd Antkowiak 1 collaboration

Christian Grasshoff 1 collaboration

Simon Wagner 1 collaboration

Niklas Jäger 1 collaboration

Nicole Meier 1 collaboration

Thimo Meyer 1 collaboration

Adrian Neu 1 collaboration

Michael Scherer 1 collaboration

Christoph Rummel 1 collaboration

Alexander Bürkle 1 collaboration

Reinhard Ullmann 1 collaboration

Benjamin Valentin Becker 1 collaboration

Hanns Leonhard Kaatsch 1 collaboration

Gerrit Schrock 1 collaboration

Jessica Müller 1 collaboration

Julia Jakobi 1 collaboration

Richard Obermair 1 collaboration

Matthias Port 1 collaboration

Harry Scherthan 1 collaboration

Florian Eggerbauer 1 collaboration

Ursula Rauen 1 collaboration

Lisa Stigler 1 collaboration

Heidrun Potschka 1 collaboration

Philipp Hörmann 1 collaboration

Gabriele Horn 1 collaboration

Catherine Schäfers 1 collaboration

Sandra Völkl 1 collaboration

Virginia Egea 1 collaboration

Karina Lutterberg 1 collaboration

Konrad Steinestel 1 collaboration

Jan Caca 1 collaboration

Andreas Nerlich 1 collaboration

Helmut Blum 1 collaboration

Sarah Reschke 1 collaboration

Sajjad Khani 1 collaboration

Alexander Bartelt 1 collaboration

Christian Weber 1 collaboration

Christian Ries 1 collaboration