Post-VX exposure treatment of rats with engineered phosphotriesterases.
Acetylcholinesterase
Catalytic bioscavenger
Detoxification
Enzyme engineering
In vivo
Organophosphate
PASylation
Phosphotriesterase
Therapy
VX
Journal
Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
25
10
2021
accepted:
09
12
2021
pubmed:
29
12
2021
medline:
29
3
2022
entrez:
28
12
2021
Statut:
ppublish
Résumé
The biologically stable and highly toxic organophosphorus nerve agent (OP) VX poses a major health threat. Standard medical therapy, consisting of reactivators and competitive muscarinic receptor antagonists, is insufficient. Recently, two engineered mutants of the Brevundimonas diminuta phosphotriesterase (PTE) with enhanced catalytic efficiency (k
Identifiants
pubmed: 34962578
doi: 10.1007/s00204-021-03199-6
pii: 10.1007/s00204-021-03199-6
pmc: PMC8837561
doi:
Substances chimiques
Chemical Warfare Agents
0
Cholinesterase Inhibitors
0
Organothiophosphorus Compounds
0
VX
9A4381183B
Phosphoric Triester Hydrolases
EC 3.1.8.-
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
571-583Informations de copyright
© 2021. The Author(s).
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