Organophosphorus compounds and oximes: a critical review.
Acetylcholinesterase
Nerve agents
Organophosphorus compounds
Oximes
Pesticides
Reactivation
Journal
Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
28
04
2020
accepted:
28
05
2020
pubmed:
9
6
2020
medline:
13
7
2021
entrez:
8
6
2020
Statut:
ppublish
Résumé
Organophosphorus (OP) pesticides and nerve agents still pose a threat to the population. Treatment of OP poisoning is an ongoing challenge and burden for medical services. Standard drug treatment consists of atropine and an oxime as reactivator of OP-inhibited acetylcholinesterase and is virtually unchanged since more than six decades. Established oximes, i.e. pralidoxime, obidoxime, TMB-4, HI-6 and MMB-4, are of insufficient effectiveness in some poisonings and often cover only a limited spectrum of the different nerve agents and pesticides. Moreover, the value of oximes in human OP pesticide poisoning is still disputed. Long-lasting research efforts resulted in the preparation of countless experimental oximes, and more recently non-oxime reactivators, intended to replace or supplement the established and licensed oximes. The progress of this development is slow and none of the novel compounds appears to be suitable for transfer into advanced development or into clinical use. This situation calls for a critical analysis of the value of oximes as mainstay of treatment as well as the potential and limitations of established and novel reactivators. Requirements for a straightforward identification of superior reactivators and their development to licensed drugs need to be addressed as well as options for interim solutions as a chance to improve the therapy of OP poisoning in a foreseeable time frame.
Identifiants
pubmed: 32506210
doi: 10.1007/s00204-020-02797-0
pii: 10.1007/s00204-020-02797-0
pmc: PMC7367912
doi:
Substances chimiques
Antidotes
0
Cholinesterase Reactivators
0
Nerve Agents
0
Organophosphonates
0
Oximes
0
Pesticides
0
Atropine
7C0697DR9I
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2275-2292Références
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