SARS-CoV-2 and pancreas: a potential pathological interaction?
Acinar Cells
/ metabolism
Angiotensin-Converting Enzyme 2
/ metabolism
COVID-19
/ metabolism
Diabetes Mellitus
/ metabolism
Glucagon-Secreting Cells
/ metabolism
Humans
Insulin-Secreting Cells
/ metabolism
Islets of Langerhans
/ metabolism
Pancreas
/ metabolism
Receptors, Coronavirus
/ metabolism
SARS-CoV-2
/ metabolism
Serine Endopeptidases
/ metabolism
Viral Tropism
ACE2
COVID-19
SARS-CoV-2
diabetes
inflammation
insulin
islets
pancreas
β-cell
Journal
Trends in endocrinology and metabolism: TEM
ISSN: 1879-3061
Titre abrégé: Trends Endocrinol Metab
Pays: United States
ID NLM: 9001516
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
20
05
2021
revised:
13
07
2021
accepted:
19
07
2021
pubmed:
11
8
2021
medline:
20
12
2022
entrez:
10
8
2021
Statut:
ppublish
Résumé
The widespread extrapulmonary complications of coronavirus disease 2019 (COVID-19) have gained momentum; the pancreas is another major target for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we take a closer look into potential pathological interactions. We provide an overview of the current knowledge and understanding of SARS-CoV-2 infection of the pancreas with a special focus on pancreatic islets and propose direct, indirect, and systemic mechanisms for pancreas injury as result of the COVID-19-diabetes fatal bidirectional relationship.
Identifiants
pubmed: 34373155
pii: S1043-2760(21)00157-0
doi: 10.1016/j.tem.2021.07.004
pmc: PMC8302839
pii:
doi:
Substances chimiques
Receptors, Coronavirus
0
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Serine Endopeptidases
EC 3.4.21.-
TMPRSS2 protein, human
EC 3.4.21.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
842-845Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no interests.
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