Microbial metabolites and the vagal afferent pathway in the control of food intake.
Kynurenine pathway
Microbial metabolites
Short chain fatty acids
Tryptophan
Vagal afferent neurons
Journal
Physiology & behavior
ISSN: 1873-507X
Titre abrégé: Physiol Behav
Pays: United States
ID NLM: 0151504
Informations de publication
Date de publication:
15 10 2021
15 10 2021
Historique:
received:
01
02
2021
revised:
06
07
2021
accepted:
06
08
2021
pubmed:
11
8
2021
medline:
26
10
2021
entrez:
10
8
2021
Statut:
ppublish
Résumé
The gut microbiota is able to influence overall energy balance via effects on both energy intake and expenditure, and is a peripheral target for potential obesity therapies. However, the precise mechanism by which the gut microbiota influences energy intake and body weight regulation is not clear. Microbes use small molecules to communicate with each other; some of these molecules are ligands at mammalian receptors and this may be a mechanism by which microbes communicate with the host. Here we briefly review the literature showing beneficial effects of microbial metabolites on food intake regulation and examine the potential role for vagal afferent neurons, the gut-brain axis.
Identifiants
pubmed: 34375620
pii: S0031-9384(21)00244-4
doi: 10.1016/j.physbeh.2021.113555
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
113555Subventions
Organisme : NCCIH NIH HHS
ID : R21 AT010933
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.