Theta-phase dependent neuronal coding during sequence learning in human single neurons.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
10 08 2021
10 08 2021
Historique:
received:
28
04
2020
accepted:
26
07
2021
entrez:
11
8
2021
pubmed:
12
8
2021
medline:
24
8
2021
Statut:
epublish
Résumé
The ability to maintain a sequence of items in memory is a fundamental cognitive function. In the rodent hippocampus, the representation of sequentially organized spatial locations is reflected by the phase of action potentials relative to the theta oscillation (phase precession). We investigated whether the timing of neuronal activity relative to the theta brain oscillation also reflects sequence order in the medial temporal lobe of humans. We used a task in which human participants learned a fixed sequence of pictures and recorded single neuron and local field potential activity with implanted electrodes. We report that spikes for three consecutive items in the sequence (the preferred stimulus for each cell, as well as the stimuli immediately preceding and following it) were phase-locked at distinct phases of the theta oscillation. Consistent with phase precession, spikes were fired at progressively earlier phases as the sequence advanced. These findings generalize previous findings in the rodent hippocampus to the human temporal lobe and suggest that encoding stimulus information at distinct oscillatory phases may play a role in maintaining sequential order in memory.
Identifiants
pubmed: 34376673
doi: 10.1038/s41467-021-25150-0
pii: 10.1038/s41467-021-25150-0
pmc: PMC8355141
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4839Informations de copyright
© 2021. The Author(s).
Références
Nat Commun. 2017 Feb 14;8:14415
pubmed: 28195129
Hippocampus. 1996;6(2):149-72
pubmed: 8797016
Elife. 2019 Jan 28;8:
pubmed: 30688649
Nature. 2005 Jun 23;435(7045):1102-7
pubmed: 15973409
PLoS One. 2009;4(2):e4338
pubmed: 19190760
J Neurophysiol. 2017 Jun 1;117(6):2269-2281
pubmed: 28331006
Cell. 2018 Nov 1;175(4):1119-1130.e15
pubmed: 30318145
Science. 2001 Feb 23;291(5508):1560-3
pubmed: 11222864
Proc Natl Acad Sci U S A. 2007 May 8;104(19):8149-54
pubmed: 17470808
Neuron. 1999 Jun;23(2):209-26
pubmed: 10399928
Nat Commun. 2015 Oct 09;6:8556
pubmed: 26449885
Curr Biol. 2017 Apr 3;27(7):1026-1032
pubmed: 28318972
Nat Neurosci. 2017 Apr;20(4):590-601
pubmed: 28218914
PLoS Biol. 2019 Jun 3;17(6):e3000290
pubmed: 31158216
Trends Neurosci. 1998 Aug;21(8):317-23
pubmed: 9720595
Neural Comput. 2004 Aug;16(8):1661-87
pubmed: 15228749
Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8918-21
pubmed: 9238078
Neuron. 1997 May;18(5):753-65
pubmed: 9182800
Neuron. 2013 Mar 20;77(6):1002-16
pubmed: 23522038
Hippocampus. 2005;15(7):881-9
pubmed: 16114040
Nat Neurosci. 2007 Feb;10(2):224-33
pubmed: 17220886
Nat Rev Neurosci. 2012 Jul 04;13(8):587-97
pubmed: 22760181
J Cogn Neurosci. 2007 Mar;19(3):479-92
pubmed: 17335396
Philos Trans R Soc Lond B Biol Sci. 2013 Dec 23;369(1635):20130304
pubmed: 24366145
Comput Intell Neurosci. 2011;2011:156869
pubmed: 21253357
Nat Rev Neurosci. 2005 Jan;6(1):35-47
pubmed: 15611725
Neuron. 2010 Nov 4;68(3):362-85
pubmed: 21040841
Brain Res. 1971 Nov;34(1):171-5
pubmed: 5124915
Neuron. 2016 Mar 16;89(6):1180-1186
pubmed: 26924436
PLoS Biol. 2018 Aug 15;16(8):e2003805
pubmed: 30110320
Science. 1971 Aug 13;173(3997):652-4
pubmed: 4998337
Hippocampus. 1993 Jul;3(3):317-30
pubmed: 8353611
Elife. 2018 Jun 22;7:
pubmed: 29932417
Nature. 2003 Sep 11;425(6954):184-8
pubmed: 12968182
Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21341-6
pubmed: 19926847
Nature. 2011 Nov 02;479(7371):103-7
pubmed: 22051680
Trends Cogn Sci. 2018 Oct;22(10):853-869
pubmed: 30266146
Nature. 2002 Jun 13;417(6890):738-41
pubmed: 12066184
Nat Neurosci. 2016 Oct;19(10):1374-80
pubmed: 27571010
J Neurosci. 2021 Feb 3;41(5):883-890
pubmed: 33257323
Curr Biol. 2010 Apr 13;20(7):606-12
pubmed: 20303266
Nature. 2010 Apr 8;464(7290):903-7
pubmed: 20336071
Curr Biol. 2017 Dec 18;27(24):3743-3751.e3
pubmed: 29199073
J Neurosci. 2001 May 1;21(9):3175-83
pubmed: 11312302
Hippocampus. 2013 Aug;23(8):656-661
pubmed: 23520039
Sci Adv. 2019 Mar 27;5(3):eaav3687
pubmed: 30944858
Hippocampus. 2005;15(7):890-900
pubmed: 16114010
Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13144-9
pubmed: 23878251
J Neurosci Methods. 2004 Mar 15;134(1):9-21
pubmed: 15102499