Long range synchronization within the enteric nervous system underlies propulsion along the large intestine in mice.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
10 08 2021
10 08 2021
Historique:
received:
25
09
2020
accepted:
15
07
2021
entrez:
11
8
2021
pubmed:
12
8
2021
medline:
3
9
2021
Statut:
epublish
Résumé
How the Enteric Nervous System (ENS) coordinates propulsion of content along the gastrointestinal (GI)-tract has been a major unresolved issue. We reveal a mechanism that explains how ENS activity underlies propulsion of content along the colon. We used a recently developed high-resolution video imaging approach with concurrent electrophysiological recordings from smooth muscle, during fluid propulsion. Recordings showed pulsatile firing of excitatory and inhibitory neuromuscular inputs not only in proximal colon, but also distal colon, long before the propagating contraction invades the distal region. During propulsion, wavelet analysis revealed increased coherence at ~2 Hz over large distances between the proximal and distal regions. Therefore, during propulsion, synchronous firing of descending inhibitory nerve pathways over long ranges aborally acts to suppress smooth muscle from contracting, counteracting the excitatory nerve pathways over this same region of colon. This delays muscle contraction downstream, ahead of the advancing contraction. The mechanism identified is more complex than expected and vastly different from fluid propulsion along other hollow smooth muscle organs; like lymphatic vessels, portal vein, or ureters, that evolved without intrinsic neurons.
Identifiants
pubmed: 34376798
doi: 10.1038/s42003-021-02485-4
pii: 10.1038/s42003-021-02485-4
pmc: PMC8355373
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
955Subventions
Organisme : NIAAA NIH HHS
ID : R01 AA027065
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR077183
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK103901
Pays : United States
Informations de copyright
© 2021. The Author(s).
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