Significance of serum palmitoleic acid levels in inflammatory bowel disease.
Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers
/ blood
Case-Control Studies
Colitis, Ulcerative
/ blood
Colonic Neoplasms
/ blood
Crohn Disease
/ blood
Fatty Acids, Monounsaturated
/ blood
Female
Humans
Male
Middle Aged
Pilot Projects
Prognosis
Retrospective Studies
Severity of Illness Index
Young Adult
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
10 08 2021
10 08 2021
Historique:
received:
08
02
2021
accepted:
28
06
2021
entrez:
11
8
2021
pubmed:
12
8
2021
medline:
9
11
2021
Statut:
epublish
Résumé
Inflammatory bowel diseases (IBDs), including ulcerative colitis (UC) and Crohn's disease (CD), are chronic intestinal diseases of unknown etiology that present with variable disease extents and outcomes. The use of biomarkers for the diagnosis and management of IBDs is considered beneficial. Palmitoleic acid (PO) is an adipose tissue-derived mono-unsaturated free fatty acid that potentially serves as a lipokine in metabolic and inflammatory diseases. The aim of this study was to investigate the significance of PO levels in the serum of patients with UC and CD. The study included patients with UC (n = 22), patients with CD (n = 35), and controls (n = 22). The levels of serum PO were analyzed using gas chromatography. The association of serum PO levels with the clinical features and disease outcomes in IBD was examined. Serum PO levels were significantly higher in patients with CD than in controls, whereas no difference in these levels was observed between patients with UC and controls. Serum PO levels were significantly associated with the CD activity index. Additionally, high serum PO levels were associated with an increased risk of surgical intervention requirement during follow-up. In a pilot study with a few patients, high PO levels were observed in the mesenteric tissue in the active disease site of patients with CD (n = 7) compared with those with colon cancer (n = 6). Elevated serum PO levels might serve as a marker for local inflammation and prognosis in patients with CD.
Identifiants
pubmed: 34376800
doi: 10.1038/s41598-021-95923-6
pii: 10.1038/s41598-021-95923-6
pmc: PMC8355139
doi:
Substances chimiques
Biomarkers
0
Fatty Acids, Monounsaturated
0
palmitoleic acid
209B6YPZ4I
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
16260Informations de copyright
© 2021. The Author(s).
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