Cancer-associated fibroblasts educate normal fibroblasts to facilitate cancer cell spreading and T-cell suppression.
CAF-educated fibroblasts
CD8+ T cells
IGF-I
asporin
kynurenine
Journal
Molecular oncology
ISSN: 1878-0261
Titre abrégé: Mol Oncol
Pays: United States
ID NLM: 101308230
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
revised:
16
07
2021
received:
12
04
2021
accepted:
10
08
2021
pubmed:
12
8
2021
medline:
9
4
2022
entrez:
11
8
2021
Statut:
ppublish
Résumé
In some tumors, a small number of cancer cells are scattered in a large fibrotic stroma. Here, we demonstrate a novel mechanism for expansion of pro-tumor fibroblasts via cancer-associated fibroblast (CAF)-mediated education of normal fibroblasts (NFs). When NFs were incubated with conditioned medium from CAFs, the resulting CAF-educated fibroblasts (CEFs) generated reactive oxygen species, which induced NF-κB-mediated expression of inflammatory cytokines and the extracellular matrix protein asporin (ASPN), while expression of a common CAF marker gene, α-SMA, was not increased. ASPN further increased CEF expression of downstream molecules, including indoleamine 2,3-dioxygenase 1 (IDO-1), kynureninase (KYNU), and pregnancy-associated plasma protein-A (PAPP-A). These CEFs induce cytocidal effects against CD8
Identifiants
pubmed: 34379869
doi: 10.1002/1878-0261.13077
pmc: PMC8732346
doi:
Substances chimiques
Extracellular Matrix Proteins
0
Banques de données
RefSeq
['NM_017680']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
166-187Informations de copyright
© 2021 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
Références
Sci Rep. 2017 Jun 23;7(1):4112
pubmed: 28646230
Front Cell Dev Biol. 2020 Jul 15;8:630
pubmed: 32760726
Br J Cancer. 2010 Mar 2;102(5):898-907
pubmed: 20145613
Oncotarget. 2016 May 10;7(19):27584-98
pubmed: 27050278
Oxid Med Cell Longev. 2016;2016:3907147
pubmed: 26798421
J Cell Mol Med. 2021 Mar;25(5):2309-2314
pubmed: 33486887
Pharmacol Ther. 2018 Mar;183:22-33
pubmed: 28942242
Cancer Cell. 2011 Feb 15;19(2):257-72
pubmed: 21316604
Blood. 2004 Jun 15;103(12):4619-21
pubmed: 15001472
Int J Tryptophan Res. 2016 Oct 12;9:67-77
pubmed: 27773992
Breast Cancer Res. 2020 Oct 27;22(1):113
pubmed: 33109232
Cancer Res. 2012 Nov 15;72(22):5649-57
pubmed: 23144293
Carcinogenesis. 2008 Apr;29(4):713-21
pubmed: 18258605
Proteomics. 2019 Apr;19(8):e1800148
pubmed: 30582284
Nat Commun. 2018 Dec 4;9(1):5150
pubmed: 30514914
Nat Commun. 2018 May 3;9(1):1777
pubmed: 29725014
Transpl Int. 2005 Jan;18(1):95-100
pubmed: 15612990
Br J Pharmacol. 2017 Jun;174(12):1533-1554
pubmed: 28332701
Oncogene. 2019 Jul;38(28):5566-5579
pubmed: 31147602
Cell Death Differ. 2002 Oct;9(10):1069-77
pubmed: 12232795
Clin Exp Metastasis. 2019 Apr;36(2):71-86
pubmed: 30847799
Cancer Sci. 2005 Jun;96(6):323-32
pubmed: 15958054
Cancer Discov. 2019 Aug;9(8):1102-1123
pubmed: 31197017
Oncotarget. 2016 Aug 9;7(32):52045-52060
pubmed: 27409832
Int J Cancer. 2016 Mar 1;138(5):1058-66
pubmed: 25784597
Clin Transl Oncol. 2021 Feb;23(2):418-423
pubmed: 32533317
Cancers (Basel). 2018 Oct 29;10(11):
pubmed: 30380628
J Exp Med. 2005 Jan 3;201(1):105-15
pubmed: 15630139
J Cell Biol. 2014 Jul 7;206(1):113-27
pubmed: 25002680
Cancer Cell. 2018 Mar 12;33(3):463-479.e10
pubmed: 29455927
Cancer Res. 2007 Nov 15;67(22):11045-53
pubmed: 18006851
Mol Cancer Ther. 2009 Jan;8(1):261-73
pubmed: 19139136
Oncogene. 2019 Jun;38(25):4887-4901
pubmed: 30816343
World J Gastroenterol. 2014 Dec 21;20(47):17804-18
pubmed: 25548479
Cancer Lett. 2017 Jul 10;398:24-36
pubmed: 28400334
Ann Endocrinol (Paris). 2016 Jun;77(2):90-6
pubmed: 27155776
Nat Rev Cancer. 2020 Mar;20(3):174-186
pubmed: 31980749
J Immunol. 2010 Sep 15;185(6):3190-8
pubmed: 20720200
Nat Genet. 2017 May;49(5):708-718
pubmed: 28319088
J Exp Clin Cancer Res. 2020 Jun 16;39(1):112
pubmed: 32546182
Br J Pharmacol. 2019 Feb;176(3):337-354
pubmed: 30381825
Oncogene. 2015 Jan 29;34(5):650-60
pubmed: 24441039
Cancer Sci. 2021 Mar;112(3):1251-1261
pubmed: 33393151
Br J Cancer. 2017 Mar 14;116(6):775-784
pubmed: 28152543
Cell Cycle. 2010 Sep 1;9(17):3515-33
pubmed: 20855962
Hypertension. 2015 Dec;66(6):1220-6
pubmed: 26483345
Sci Rep. 2018 Mar 1;8(1):3888
pubmed: 29497093
Biochem Biophys Res Commun. 2003 Sep 12;309(1):232-40
pubmed: 12943687
Br J Cancer. 2011 Sep 27;105(7):996-1001
pubmed: 21863023
PLoS One. 2012;7(11):e48799
pubmed: 23152806
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016 Dec;160(4):467-473
pubmed: 27605398
Cancer Res. 2019 Oct 15;79(20):5367-5381
pubmed: 31439548