Epstein-Barr virus oral shedding and viremia and their association with oral hairy leukoplakia in HIV+ individuals.
Epstein-Barr virus
oral hairy leukoplakia
oral manifestations of HIV
Journal
Oral diseases
ISSN: 1601-0825
Titre abrégé: Oral Dis
Pays: Denmark
ID NLM: 9508565
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
revised:
23
07
2021
received:
03
05
2021
accepted:
03
08
2021
pubmed:
12
8
2021
medline:
8
2
2023
entrez:
11
8
2021
Statut:
ppublish
Résumé
To assess the oral shedding and viremia of Epstein-Barr virus (EBV) in HIV-positive patients and their relationship with oral hairy leukoplakia (OHL). A total of 94 HIV-positive patients were included in the study, in which blood and saliva samples were collected for EBV quantification. Data on gender, age, time of HIV seropositivity, combined antiretroviral therapy (cART), CD4+ T-cell counts, and HIV viral load were collected. OHL diagnosis was based on histopathological examination and EBV in situ hybridization. The EBV load in the 94 HIV-positive patients was higher in saliva than in blood (2.4 and 1.6, respectively), and there was a positive correlation between EBV oral shedding and viremia (p = 0.001). Twenty (21.27%) patients had OHL and also a higher EBV load in saliva (mean log In HIV-positive patients, the presence of OHL was associated with EBV oral shedding but not with viremia, regardless of the amount of circulating CD4+ T cells.
Types de publication
Journal Article
Langues
eng
Pagination
796-802Informations de copyright
© 2021 Wiley Periodicals LLC.
Références
Barone, R., Ficarra, G., Gaglioti, D., Orsi, A., & Mazzotta, F. (1990). Prevalence of oral lesions among HIV-infected intravenous drug abusers and other risk groups. Oral Surgery, Oral Medicine, and Oral Pathology, 69(2), 169-173. https://doi.org/10.1016/0030-4220(90)90322-j
Basso, M., Andreis, S., Scaggiante, R., Franchin, E., Zago, D., Biasolo, M. A., Del Vecchio, C., Mengoli, C., Sarmati, L., Andreoni, M., Palù, G., & Parisi, S. G. (2018). Cytomegalovirus, Epstein-Barr virus and human herpesvirus 8 salivary shedding in HIV positive men who have sex with men with controlled and uncontrolled plasma HIV viremia: a 24-month longitudinal study. BMC Infectious Diseases, 18(1), 683. https://doi.org/10.1186/s12879-018-3591-x
Braz-Silva, P. H., de Rezende, N. P., Ortega, K. L., de Macedo Santos, R. T., & de Magalhães, M. H. (2008). Detection of the Epstein-Barr virus (EBV) by in situ hybridization as definitive diagnosis of hairy leukoplakia. Head and Neck Pathology, 2(1), 19-24. https://doi.org/10.1007/s12105-007-0039-9
Braz-Silva, P. H., Ortega, K. L., Rezende, N. P., Nunes, F. D., & Magalhães, M. H. (2006). Detection of Epstein-Barr virus (EBV) in the oral mucosa of renal transplant patients. Diagnostic Cytopathology, 34(1), 24-28. https://doi.org/10.1002/dc.20380
Braz-Silva, P. H., Schussel, J. L., López Ortega, K., & Gallottini, M. (2017). Oral lesions as an important marker for HIV progression. Dermatology Online Journal, 23(9), 13030/qt9t26m7n3. https://doi.org/10.5070/D3239036491
Cannizzo, E. S., Bellistrì, G. M., Casabianca, A., Tincati, C., Iannotti, N., Barco, A., Orlandi, C., Monforte, A. A., & Marchetti, G. (2015). Immunophenotype and function of CD38-expressing CD4+ and CD8+ T cells in HIV-infected patients undergoing suppressive combination antiretroviral therapy. The Journal of Infectious Diseases, 211(9), 1511-1513. https://doi.org/10.1093/infdis/jiu634
Chambers, A. E., Conn, B., Pemberton, M., Robinson, M., Banks, R., & Sloan, P. (2015). Twenty-first-century oral hairy leukoplakia-a non-HIV-associated entity. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 119(3), 326-332. https://doi.org/10.1016/j.oooo.2014.11.012
Conley, L. J., Bush, T. J., Buchbinder, S. P., Penley, K. A., Judson, F. N., & Holmberg, S. D. (1996). The association between cigarette smoking and selected HIV-related medical conditions. AIDS, 10(10), 1121-1126.
El Howati, A., & Tappuni, A. (2018). Systematic review of the changing pattern of the oral manifestations of HIV. Journal of Investigative and Clinical Dentistry, 9(4), e12351. https://doi.org/10.1111/jicd.12351
Fan, H., & Gulley, M. L. (2001). Epstein-Barr viral load measurement as a marker of EBV-related disease. Molecular Diagnosis, 6(4), 279-289. https://doi.org/10.1054/modi.2001.29161
Franco, J. B., Maureira Pena, L. J., Martins E Martins, F., de Oliveira, M. A., & Ortega, K. L. (2019). Regression of human immunodeficiency virus-associated oral Kaposi sarcoma with combined antiretroviral therapy: A case report and literature review. Head & Neck, 41(2), E21-E25. https://doi.org/10.1002/hed.25446
Glick, M., Muzyka, B. C., Lurie, D., & Salkin, L. M. (1994). Oral manifestations associated with HIV-related disease as markers for immune suppression and AIDS. Oral Surgery, Oral Medicine, and Oral Pathology, 77(4), 344-349. https://doi.org/10.1016/0030-4220(94)90195-3
Greenspan, J. S., Greenspan, D., Lennette, E. T., Abrams, D. I., Conant, M. A., Petersen, V., & Freese, U. K. (1985). Replication of Epstein-Barr virus within the epithelial cells of oral "hairy" leukoplakia, an AIDS-associated lesion. The New England Journal of Medicine, 313(25), 1564-1571. https://doi.org/10.1056/NEJM198512193132502
Greenspan, J. S., Greenspan, D., & Webster-Cyriaque, J. (2016). Hairy leukoplakia; lessons learned: 30-plus years. Oral Diseases, 22(Suppl 1), 120-127. https://doi.org/10.1111/odi.12393
Kerdpon, D., Pongsiriwet, S., Pangsomboon, K., Iamaroon, A., Kampoo, K., Sretrirutchai, S., Geater, A., & Robison, V. (2004). Oral manifestations of HIV infection in relation to clinical and CD4 immunological status in northern and southern Thai patients. Oral Diseases, 10(3), 138-144. https://doi.org/10.1046/j.1601-0825.2003.00990.x
Kerr, J. R. (2019). Epstein-Barr virus (EBV) reactivation and therapeutic inhibitors. Journal of Clinical Pathology, 72(10), 651-658. https://doi.org/10.1136/jclinpath-2019-205822
Khammissa, R. A., Fourie, J., Chandran, R., Lemmer, J., & Feller, L. (2016). Epstein-Barr virus and its association with oral hairy leukoplakia: A short review. International Journal of Dentistry, 2016, 4941783. https://doi.org/10.1155/2016/4941783
Kusiak, A., Maj, A., Cichońska, D., Kochańska, B., Cydejko, A., & Świetlik, D. (2020). The analysis of the frequency of leukoplakia in reference of tobacco smoking among northern polish population. International Journal of Environmental Research and Public Health, 17(18), 6919. https://doi.org/10.3390/ijerph17186919
Long, H. M., Meckiff, B. J., & Taylor, G. S. (2019). The T-cell response to Epstein-Barr Virus-new tricks from an old dog. Frontiers in Immunology, 10, 2193. https://doi.org/10.3389/fimmu.2019.02193
Martins, F. M., Casseb, J., Penalva-de-Oliveira, A. C., de Paiva, M. F., Watanuki, F., & Ortega, K. L. (2010). Oral manifestations of human T-cell lymphotropic virus infection in adult patients from Brazil. Oral Diseases, 16(2), 167-171. https://doi.org/10.1111/j.1601-0825.2009.01638.x
Martins, L. L., Rosseto, J., Andrade, N. S., Franco, J. B., Braz-Silva, P. H., & Ortega, K. L. (2017). Diagnosis of oral hairy leukoplakia: The importance of EBV in situ hybridization. International Journal of Dentistry, 2017, 3457479. https://doi.org/10.1155/2017/3457479
Miziara, I. D., & Weber, R. (2006). Oral candidosis and oral hairy leukoplakia as predictors of HAART failure in Brazilian HIV-infected patients. Oral Diseases, 12(4), 402-407. https://doi.org/10.1111/j.1601-0825.2005.01214.x.
Moreno, S., & Serrano-Villar, S. (2016). Beyond undetectable viral load: Effect of nucleotides on inflammation. EBioMedicine, 13, 31-32. https://doi.org/10.1016/j.ebiom.2016.10.015
Moura, M. D., Grossmann, S., Fonseca, L. M., Senna, M. I., & Mesquita, R. A. (2006). Risk factors for oral hairy leukoplakia in HIV-infected adults of Brazil. Journal of Oral Pathology & Medicine, 35(6), 321-326. https://doi.org/10.1111/j.1600-0714.2006.00428.x
Nikiforow, S., Bottomly, K., & Miller, G. (2001). CD4+ T-cell effectors inhibit Epstein-Barr virus-induced B-cell proliferation. Journal of Virology, 75(8), 3740-3752. https://doi.org/10.1128/JVI.75.8.3740-3752.2001
Nittayananta, W., Tao, R., Jiang, L., Peng, Y., & Huang, Y. (2016). Oral innate immunity in HIV infection in HAART era. Journal of Oral Pathology & Medicine, 45(1), 3-8. https://doi.org/10.1111/jop.12304
Ortega, K. L., Ceballos-Salobreña, A., Gaitán-Cepeda, L. A., & Magalhães, M. G. (2008). Oral manifestations after immune reconstitution in HIV patients on HAART. International Journal of STD & AIDS, 19(5), 305-308. https://doi.org/10.1258/ijsa.2007.007261
Ortega, K. L., Vale, D. A., & Magalhães, M. H. (2009). Impact of PI and NNRTI HAART-based therapy on oral lesions of Brazilian HIV-infected patients. Journal of Oral Pathology & Medicine, 38(6), 489-494. https://doi.org/10.1111/j.1600-0714.2009.00783.x
Patton, L. L., Ramirez-Amador, V., Anaya-Saavedra, G., Nittayananta, W., Carrozzo, M., & Ranganathan, K. (2013). Urban legends series: oral manifestations of HIV infection. Oral Diseases, 19(6), 533-550. https://doi.org/10.1111/odi.12103
Ravina, A., Ficarra, G., Chiodo, M., Mazzetti, M., & Romagnani, S. (1996). Relationship of circulating CD4+ T-lymphocytes and p24 antigenemia to the risk of developing AIDS in HIV-infected subjects with oral hairy leukoplakia. Journal of Oral Pathology & Medicine, 25(3), 108-111. https://doi.org/10.1111/j.1600-0714.1996.tb00203.x
Shiboski, C. H., Hilton, J. F., Neuhaus, J. M., Canchola, A., & Greenspan, D. (1996). Human immunodeficiency virus-Related oral manifestations and gender. A longitudinal analysis. Archives of Internal Medicine, 156(19), 2249-2254. https://doi.org/10.1001/archinte.1996.00440180113014
Sroussi, H. Y., Villines, D., Epstein, J., Alves, M. C., & Alves, M. E. (2007). Oral lesions in HIV-positive dental patients-one more argument for tobacco smoking cessation. Oral Diseases, 13(3), 324-328. https://doi.org/10.1111/j.1601-0825.2006.01289.x
Tappuni, A. R. (2020). The global changing pattern of the oral manifestations of HIV. Oral Diseases, 26(Suppl 1), 22-27. https://doi.org/10.1111/odi.13469
Trigueiro, M., Tedeschi-Oliveira, S. V., Melani, R. F., & Ortega, K. L. (2010). An assessment of adverse effects of antiretroviral therapy on the development of HIV positive children by observation of dental mineralization chronology. Journal of Oral Pathology & Medicine, 39(1), 35-40. https://doi.org/10.1111/j.1600-0714.2009.00856.x
Vale, D. A., Martins, F. M., Silva, P. H., & Ortega, K. L. (2016). Retrospective analysis of the clinical behavior of oral hairy leukoplakia in 215 HIV-seropositive patients. Brazilian Oral Research, 30(1), e118. https://doi.org/10.1590/1807-3107BOR-2016.vol30.0118
Vandormael, A., Akullian, A., Siedner, M., de Oliveira, T., Bärnighausen, T., & Tanser, F. (2019). Declines in HIV incidence among men and women in a South African population-based cohort. Nature Communications, 10(1), 5482. https://doi.org/10.1038/s41467-019-13473-y
Walling, D. M., Flaitz, C. M., Hosein, F. G., Montes-Walters, M., & Nichols, C. M. (2004). Effect of Epstein-Barr virus replication on Langerhans cells in pathogenesis of oral hairy leukoplakia. The Journal of Infectious Diseases, 189(9), 1656-1663. https://doi.org/10.1086/383132
Walling, D. M., Flaitz, C. M., Nichols, C. M., Hudnall, S. D., & Adler-Storthz, K. (2001). Persistent productive Epstein-Barr virus replication in normal epithelial cells in vivo. The Journal of Infectious Diseases, 184(12), 1499-1507. https://doi.org/10.1086/323992