Comparing the responses of the UK, Sweden and Denmark to COVID-19 using counterfactual modelling.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
11 08 2021
Historique:
received: 31 03 2021
accepted: 27 07 2021
entrez: 12 8 2021
pubmed: 13 8 2021
medline: 26 8 2021
Statut: epublish

Résumé

The UK and Sweden have among the worst per-capita COVID-19 mortality in Europe. Sweden stands out for its greater reliance on voluntary, rather than mandatory, control measures. We explore how the timing and effectiveness of control measures in the UK, Sweden and Denmark shaped COVID-19 mortality in each country, using a counterfactual assessment: what would the impact have been, had each country adopted the others' policies? Using a Bayesian semi-mechanistic model without prior assumptions on the mechanism or effectiveness of interventions, we estimate the time-varying reproduction number for the UK, Sweden and Denmark from daily mortality data. We use two approaches to evaluate counterfactuals which transpose the transmission profile from one country onto another, in each country's first wave from 13th March (when stringent interventions began) until 1st July 2020. UK mortality would have approximately doubled had Swedish policy been adopted, while Swedish mortality would have more than halved had Sweden adopted UK or Danish strategies. Danish policies were most effective, although differences between the UK and Denmark were significant for one counterfactual approach only. Our analysis shows that small changes in the timing or effectiveness of interventions have disproportionately large effects on total mortality within a rapidly growing epidemic.

Identifiants

pubmed: 34381102
doi: 10.1038/s41598-021-95699-9
pii: 10.1038/s41598-021-95699-9
pmc: PMC8358009
doi:

Types de publication

Comparative Study Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

16342

Subventions

Organisme : Medical Research Council
ID : MC_PC_19012
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R015600/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/V038109/1
Pays : United Kingdom

Informations de copyright

© 2021. The Author(s).

Références

Cytokine Growth Factor Rev. 2020 Jun;53:10-12
pubmed: 32405247
Nature. 2020 Aug;584(7820):257-261
pubmed: 32512579
N Engl J Med. 2020 Aug 20;383(8):e56
pubmed: 32767891
Phys Life Rev. 2016 Sep;18:66-97
pubmed: 27451336
Lancet. 2020 May 9;395(10235):1474
pubmed: 32386582
Nature. 2020 Aug;584(7820):262-267
pubmed: 32512578
Lancet. 2020 Jun 20;395(10241):e110-e111
pubmed: 32534627

Auteurs

Swapnil Mishra (S)

MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK. s.mishra@imperial.ac.uk.
Jameel Institute for Disease and Emergency Analytics, Imperial College London, London, UK. s.mishra@imperial.ac.uk.

James A Scott (JA)

Department of Mathematics, Imperial College London, London, UK.

Daniel J Laydon (DJ)

MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.
Jameel Institute for Disease and Emergency Analytics, Imperial College London, London, UK.

Seth Flaxman (S)

Department of Mathematics, Imperial College London, London, UK.

Axel Gandy (A)

Department of Mathematics, Imperial College London, London, UK.

Thomas A Mellan (TA)

MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.
Jameel Institute for Disease and Emergency Analytics, Imperial College London, London, UK.

H Juliette T Unwin (HJT)

MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.
Jameel Institute for Disease and Emergency Analytics, Imperial College London, London, UK.

Michaela Vollmer (M)

MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.
Jameel Institute for Disease and Emergency Analytics, Imperial College London, London, UK.

Helen Coupland (H)

MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.
Jameel Institute for Disease and Emergency Analytics, Imperial College London, London, UK.

Oliver Ratmann (O)

MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.
Jameel Institute for Disease and Emergency Analytics, Imperial College London, London, UK.

Melodie Monod (M)

MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.
Jameel Institute for Disease and Emergency Analytics, Imperial College London, London, UK.

Harrison H Zhu (HH)

MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.
Jameel Institute for Disease and Emergency Analytics, Imperial College London, London, UK.

Anne Cori (A)

MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.
Jameel Institute for Disease and Emergency Analytics, Imperial College London, London, UK.

Katy A M Gaythorpe (KAM)

MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.
Jameel Institute for Disease and Emergency Analytics, Imperial College London, London, UK.

Lilith K Whittles (LK)

MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.
Jameel Institute for Disease and Emergency Analytics, Imperial College London, London, UK.

Charles Whittaker (C)

MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.
Jameel Institute for Disease and Emergency Analytics, Imperial College London, London, UK.

Christl A Donnelly (CA)

MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.
Department of Statistics, University of Oxford, Oxford, UK.

Neil M Ferguson (NM)

MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK. neil.ferguson@imperial.ac.uk.
Jameel Institute for Disease and Emergency Analytics, Imperial College London, London, UK. neil.ferguson@imperial.ac.uk.

Samir Bhatt (S)

MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.
Jameel Institute for Disease and Emergency Analytics, Imperial College London, London, UK.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH