Decidualized endometrial stromal cells present with altered androgen response in PCOS.

Adult Androgens / metabolism Dihydrotestosterone / metabolism Endometrium / metabolism Estradiol / metabolism Female Humans Polycystic Ovary Syndrome / metabolism Pregnancy Progesterone / metabolism Signal Transduction / physiology Stromal Cells / metabolism

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
11 08 2021
Historique:
received: 11 06 2021
accepted: 23 07 2021
entrez: 12 8 2021
pubmed: 13 8 2021
medline: 16 11 2021
Statut: epublish

Résumé

Hyperandrogenic women with PCOS show disrupted decidualization (DE) and placentation. Dihydrotestosterone (DHT) is reported to enhance DE in non-PCOS endometrial stromal cells (eSC

Identifiants

DOI: 10.1038/s41598-021-95705-0 PMID: 34381107 PMC: PMC8357821
pubmed: 34381107
doi: 10.1038/s41598-021-95705-0
pii: 10.1038/s41598-021-95705-0
pmc: PMC8357821
doi:

Substances chimiques

Androgens 0
Dihydrotestosterone 08J2K08A3Y
Progesterone 4G7DS2Q64Y
Estradiol 4TI98Z838E

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

16287

Informations de copyright

© 2021. The Author(s).

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Auteurs

Masuma Khatun (M)

Department of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland.

Alvin Meltsov (A)

Competence Centre on Health Technologies, Tartu, Estonia.
Department of Computer Science, University of Tartu, Tartu, Estonia.

Darja Lavogina (D)

Competence Centre on Health Technologies, Tartu, Estonia.
Institute of Chemistry, University of Tartu, Tartu, Estonia.

Marina Loid (M)

Competence Centre on Health Technologies, Tartu, Estonia.
Department of Obstetrics and Gynaecology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.

Keiu Kask (K)

Competence Centre on Health Technologies, Tartu, Estonia.
Department of Obstetrics and Gynaecology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.

Riikka K Arffman (RK)

Department of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland.

Henna-Riikka Rossi (HR)

Department of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland.

Freddy Lättekivi (F)

Department of Pathophysiology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Institute of Veterinary Medicine and Animal Sciences, Estonian University of Life Sciences, Tartu, Estonia.

Kersti Jääger (K)

Competence Centre on Health Technologies, Tartu, Estonia.

Kaarel Krjutškov (K)

Competence Centre on Health Technologies, Tartu, Estonia.
Department of Obstetrics and Gynaecology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.

Ago Rinken (A)

Institute of Chemistry, University of Tartu, Tartu, Estonia.

Andres Salumets (A)

Competence Centre on Health Technologies, Tartu, Estonia.
Department of Obstetrics and Gynaecology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.
Division of Obstetrics and Gynaecology, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.

Terhi T Piltonen (TT)

Department of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland. terhi.piltonen@oulu.fi.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Decidualized endometrial stromal cells present...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Androgènes › Decidualized endometrial stromal cells present...
questionsmedicales.fr › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de la testostérone › 5alpha-Dihydrotestostérone › Decidualized endometrial stromal cells present...
questionsmedicales.fr › Appareil urogénital › Système génital › Système génital de la femme › Utérus › Endomètre › Decidualized endometrial stromal cells present...
questionsmedicales.fr › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de l'oestradiol › Oestradiol › Decidualized endometrial stromal cells present...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Decidualized endometrial stromal cells present...
questionsmedicales.fr › Maladies endocriniennes › Troubles gonadiques › Maladies ovariennes › Kystes de l'ovaire › Syndrome des ovaires polykystiques › Decidualized endometrial stromal cells present...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Decidualized endometrial stromal cells present...
questionsmedicales.fr › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de la progestérone › Progestérone › Decidualized endometrial stromal cells present...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Decidualized endometrial stromal cells present...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Cellules stromales › Decidualized endometrial stromal cells present...