Endothelium-specific deletion of amyloid-β precursor protein exacerbates endothelial dysfunction induced by aging.

Aging / physiology Amyloid beta-Protein Precursor / genetics Animals Aorta, Thoracic / drug effects Cyclooxygenase 2 / metabolism Cyclooxygenase Inhibitors / pharmacology Endothelium, Vascular / drug effects Indomethacin / pharmacology Male Mice Mice, Knockout Nitric Oxide Synthase Type III / metabolism Prostaglandins / metabolism Vasoconstriction / drug effects Vasodilation / drug effects
aging amyloid precursor protein endothelial nitric oxide synthase endothelium prostaglandins

Journal

Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617

Informations de publication

Date de publication:
12 08 2021
Historique:
received: 29 03 2021
accepted: 30 07 2021
pubmed: 13 8 2021
medline: 12 1 2022
entrez: 12 8 2021
Statut: ppublish

Résumé

The physiological function of amyloid precursor protein (APP) in the control of endothelial function during aging is unclear. Aortas of young (4-6 months old) and aged (23-26 months old) wild-type (WT) and endothelium-specific APP-deficient (eAPP

Identifiants

DOI: 10.18632/aging.203401 PMID: 34382945 PMC: PMC8386539
pubmed: 34382945
pii: 203401
doi: 10.18632/aging.203401
pmc: PMC8386539
doi:

Substances chimiques

APP protein, mouse 0
Amyloid beta-Protein Precursor 0
Cyclooxygenase Inhibitors 0
Prostaglandins 0
Nitric Oxide Synthase Type III EC 1.14.13.39
Cyclooxygenase 2 EC 1.14.99.1
Indomethacin XXE1CET956

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

19165-19185

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL131515
Pays : United States

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Auteurs

Livius V d'Uscio (LV)

Departments of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN 55902, USA.

Zvonimir S Katusic (ZS)

Departments of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN 55902, USA.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Endothelium-specific deletion of amyloid-β...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines sécrétoires inhibitrices de protéinases › Protéase nexines › Précurseur de la protéine bêta-amyloïde › Endothelium-specific deletion of amyloid-β...
questionsmedicales.fr › Eucaryotes › Animaux › Endothelium-specific deletion of amyloid-β...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Artères › Aorte › Aorte thoracique › Endothelium-specific deletion of amyloid-β...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Complexes multienzymatiques › Cyclooxygenase 2 › Endothelium-specific deletion of amyloid-β...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antirhumatismaux › Anti-inflammatoires non stéroïdiens › Inhibiteurs des cyclooxygénases › Endothelium-specific deletion of amyloid-β...
questionsmedicales.fr › Tissus › Épithélium › Endothélium › Endothélium vasculaire › Endothelium-specific deletion of amyloid-β...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indoles › Indométacine › Endothelium-specific deletion of amyloid-β...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Endothelium-specific deletion of amyloid-β...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Endothelium-specific deletion of amyloid-β...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-NH2 group donors › Amino-acid oxidoreductases › Nitric oxide synthase › Nitric oxide synthase type III › Endothelium-specific deletion of amyloid-β...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Éicosanoïdes › Prostaglandines › Endothelium-specific deletion of amyloid-β...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Vasoconstriction › Endothelium-specific deletion of amyloid-β...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Vasodilatation › Endothelium-specific deletion of amyloid-β...