Cardiovascular Outcomes in Patients With Mitochondrial Disease in the United States: A Propensity Score Analysis.
Adult
Cardiovascular Diseases
/ epidemiology
Cross-Sectional Studies
Female
Follow-Up Studies
Hospital Mortality
/ trends
Humans
Incidence
Inpatients
Male
Middle Aged
Mitochondrial Diseases
/ complications
Propensity Score
Risk Assessment
/ methods
Risk Factors
Survival Rate
/ trends
United States
Young Adult
Cardiovascular diseases
cohort studies
heart failure, inpatients/statistics & numerical data
mitochondrial diseases
propensity score
Journal
Texas Heart Institute journal
ISSN: 1526-6702
Titre abrégé: Tex Heart Inst J
Pays: United States
ID NLM: 8214622
Informations de publication
Date de publication:
01 Jul 2021
01 Jul 2021
Historique:
entrez:
12
8
2021
pubmed:
13
8
2021
medline:
7
9
2021
Statut:
ppublish
Résumé
Mitochondrial disease comprises a wide range of genetic disorders caused by mitochondrial dysfunction. Its rarity, however, has limited the ability to assess its effects on clinical outcomes. To evaluate this relationship, we collected data from the 2016 National Inpatient Sample, which includes data from >7 million hospital stays. We identified 705 patients (mean age, 22 ± 20.7 yr; 54.2% female; 67.4% white) whose records included the ICD-10-CM code E88.4. We also identified a propensity-matched cohort of 705 patients without mitochondrial disease to examine the effect of mitochondrial disease on major adverse cardiovascular events, including all-cause in-hospital death, cardiac arrest, and acute congestive heart failure. Patients with mitochondrial disease were at significantly greater risk of major adverse cardiovascular events (odds ratio [OR]=2.42; 95% CI, 1.29-4.57; P=0.005), systolic heart failure (OR=2.37; 95% CI, 1.08-5.22; P=0.027), and all-cause in-hospital death (OR=14.22; 95% CI, 1.87-108.45; P<0.001). These findings suggest that mitochondrial disease significantly increases the risk of inpatient major adverse cardiovascular events.
Identifiants
pubmed: 34383956
pii: 469117
doi: 10.14503/THIJ-20-7243
pmc: PMC8367288
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2021 by the Texas Heart® Institute, Houston.
Références
BMC Cardiovasc Disord. 2002 Aug 01;2:12
pubmed: 12150714
Circ Res. 2016 Jun 10;118(12):1960-91
pubmed: 27126807
Am J Hum Genet. 2003 Feb;72(2):333-9
pubmed: 12518276
Curr Opin Rheumatol. 2006 Nov;18(6):636-41
pubmed: 17053512
J Neurol Sci. 1980 Jul;47(1):117-33
pubmed: 6774061
Biochim Biophys Acta. 2012 May;1820(5):619-24
pubmed: 21443929
Eur J Paediatr Neurol. 2007 Jul;11(4):208-14
pubmed: 17434771
Eur Heart J. 2003 Feb;24(3):280-8
pubmed: 12590906
N Engl J Med. 2012 Mar 22;366(12):1132-41
pubmed: 22435372
Heart Fail Rev. 2016 Jan;21(1):103-116
pubmed: 26712328
Science. 2012 Aug 31;337(6098):1052-4
pubmed: 22936767
Am J Hum Genet. 1998 Aug;63(2):447-54
pubmed: 9683591
J Clin Invest. 2013 Apr;123(4):1405-12
pubmed: 23543062
Tex Heart Inst J. 2013;40(4):385-94
pubmed: 24082366
J Am Coll Cardiol. 2000 Aug;36(2):493-500
pubmed: 10933363
Heart. 2003 Jul;89(7):791-2
pubmed: 12807863
Eur Heart J. 2012 Dec;33(24):3023-33
pubmed: 22936362
J Neurol Sci. 1991 Oct;105(2):217-24
pubmed: 1661776
Am J Cardiol. 2007 Jan 15;99(2):264-9
pubmed: 17223431
Circulation. 1995 Feb 15;91(4):955-61
pubmed: 7850981
Pediatr Cardiol. 2009 Jul;30(5):659-81
pubmed: 19184181
Mol Genet Metab. 2017 Jun;121(2):119-126
pubmed: 28442181
Eur Heart J. 2008 Jan;29(1):89-95
pubmed: 17993472
Eur Heart J. 2015 Nov 7;36(42):2886-93
pubmed: 26224072
Stat Sci. 2010 Feb 1;25(1):1-21
pubmed: 20871802
Neurology. 2010 Feb 23;74(8):674-7
pubmed: 20177121
Am J Hum Genet. 2008 Aug;83(2):254-60
pubmed: 18674747
Cold Spring Harb Symp Quant Biol. 2011;76:1-16
pubmed: 22194359
Annu Rev Physiol. 2010;72:19-44
pubmed: 20148665
Eur J Heart Fail. 2010 Feb;12(2):114-21
pubmed: 20083621
Ann Neurol. 2000 Aug;48(2):188-93
pubmed: 10939569