Generation of striatal neurons from human induced pluripotent stem cells by controlling extrinsic signals with small molecules.

Cell Differentiation Corpus Striatum / metabolism Dopamine and cAMP-Regulated Phosphoprotein 32 / genetics Hedgehog Proteins / metabolism Humans Induced Pluripotent Stem Cells / metabolism Neurons / metabolism
Human induced pluripotent stem cells Lateral ganglionic eminence Medium spiny neurons Regional patterning Striatal neurons

Journal

Stem cell research
ISSN: 1876-7753
Titre abrégé: Stem Cell Res
Pays: England
ID NLM: 101316957

Informations de publication

Date de publication:
08 2021
Historique:
received: 27 02 2021
revised: 07 07 2021
accepted: 30 07 2021
pubmed: 14 8 2021
medline: 27 10 2021
entrez: 13 8 2021
Statut: ppublish

Résumé

Human induced pluripotent stem cells (hiPSCs) are powerful tools for modeling human brain development and treating neurodegenerative diseases. Here we established a robust protocol with high scalability for generating striatal medium spiny neurons (MSNs) from hiPSCs using small molecules under two- and three-dimensional culture conditions. Using this protocol, GSH2

Identifiants

DOI: 10.1016/j.scr.2021.102486 PMID: 34385043
pubmed: 34385043
pii: S1873-5061(21)00333-0
doi: 10.1016/j.scr.2021.102486
pii:
doi:

Substances chimiques

Dopamine and cAMP-Regulated Phosphoprotein 32 0
Hedgehog Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

102486

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Auteurs

Naoya Amimoto (N)

Division of Integrated Pharmaceutical Science, Kyoto Pharmaceutical University, Kyoto 607-8414, Japan.

Kaneyasu Nishimura (K)

Division of Integrated Pharmaceutical Science, Kyoto Pharmaceutical University, Kyoto 607-8414, Japan. Electronic address: k-nishimura@mb.kyoto-phu.ac.jp.

Shun Shimohama (S)

Department of Neurology, Sapporo Medical University, School of Medicine, Sapporo 060-8543, Japan.

Kazuyuki Takata (K)

Division of Integrated Pharmaceutical Science, Kyoto Pharmaceutical University, Kyoto 607-8414, Japan.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Generation of striatal neurons from human...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Corps strié › Generation of striatal neurons from human...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › Phosphoprotéine DARPP-32 régulée par la dopamine et l'AMPc › Generation of striatal neurons from human...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines Hedgehog › Generation of striatal neurons from human...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Generation of striatal neurons from human...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches pluripotentes › Cellules souches pluripotentes induites › Generation of striatal neurons from human...
questionsmedicales.fr › Cellules › Neurones › Generation of striatal neurons from human...