Durability of mRNA-1273 vaccine-induced antibodies against SARS-CoV-2 variants.
2019-nCoV Vaccine mRNA-1273
Adolescent
Adult
Aged
Antibodies, Neutralizing
/ blood
Antibodies, Viral
/ blood
COVID-19
/ prevention & control
COVID-19 Vaccines
/ administration & dosage
Cross Reactions
Humans
Immune Evasion
Immunization, Secondary
Immunogenicity, Vaccine
Middle Aged
SARS-CoV-2
/ immunology
Time Factors
Young Adult
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
17 Sep 2021
17 Sep 2021
Historique:
pubmed:
14
8
2021
medline:
25
9
2021
entrez:
13
8
2021
Statut:
ppublish
Résumé
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutations may diminish vaccine-induced protective immune responses, particularly as antibody titers wane over time. Here, we assess the effect of SARS-CoV-2 variants B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma), B.1.429 (Epsilon), B.1.526 (Iota), and B.1.617.2 (Delta) on binding, neutralizing, and angiotensin-converting enzyme 2 (ACE2)–competing antibodies elicited by the messenger RNA (mRNA) vaccine mRNA-1273 over 7 months. Cross-reactive neutralizing responses were rare after a single dose. At the peak of response to the second vaccine dose, all individuals had responses to all variants. Binding and functional antibodies against variants persisted in most subjects, albeit at low levels, for 6 months after the primary series of the mRNA-1273 vaccine. Across all assays, B.1.351 had the lowest antibody recognition. These data complement ongoing studies to inform the potential need for additional boost vaccinations.
Identifiants
pubmed: 34385356
pii: science.abj4176
doi: 10.1126/science.abj4176
pmc: PMC8691522
mid: NIHMS1761636
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
COVID-19 Vaccines
0
2019-nCoV Vaccine mRNA-1273
EPK39PL4R4
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1372-1377Subventions
Organisme : NIAID NIH HHS
ID : R21 AI158788
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : Intramural NIH HHS
ID : Z99 AI999999
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI148373
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI148684
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201500002C
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI151698
Pays : United States
Organisme : NIH HHS
ID : P51 OD011132
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI148576
Pays : United States
Commentaires et corrections
Type : UpdateOf
Références
Science. 2021 Aug 13;373(6556):
pubmed: 34210892
N Engl J Med. 2020 Nov 12;383(20):1920-1931
pubmed: 32663912
N Engl J Med. 2021 Jun 17;384(24):2352-2354
pubmed: 33826819
Semin Immunol. 2018 Dec;40:83-94
pubmed: 30501873
Cell Host Microbe. 2021 Apr 14;29(4):516-521.e3
pubmed: 33798491
N Engl J Med. 2020 Dec 17;383(25):2427-2438
pubmed: 32991794
Cell Res. 2021 Jun;31(6):720-722
pubmed: 33893398
Cell Host Microbe. 2021 Jan 13;29(1):23-31.e4
pubmed: 33306985
N Engl J Med. 2021 Mar 17;384(15):1468-1470
pubmed: 33730471
J Biol Chem. 2021 Jan-Jun;296:100536
pubmed: 33716040
Lancet Infect Dis. 2022 Dec;22(12):e370-e376
pubmed: 36057267
Nature. 2021 Jul;595(7867):426-431
pubmed: 34126625
Cell Rep. 2021 Apr 20;35(3):109017
pubmed: 33857422
Nature. 2021 May;593(7857):130-135
pubmed: 33684923
Lancet. 2021 Jun 26;397(10293):2461-2462
pubmed: 34139198
Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11382-8
pubmed: 8876144
N Engl J Med. 2021 Sep 2;385(10):951-953
pubmed: 34260834
Curr Protoc Immunol. 2020 Dec;131(1):e116
pubmed: 33215858
Science. 2020 Mar 13;367(6483):1260-1263
pubmed: 32075877
N Engl J Med. 2021 Jul 8;385(2):187-189
pubmed: 33951357
N Engl J Med. 2020 Feb 20;382(8):727-733
pubmed: 31978945
Nat Med. 2021 Apr;27(4):622-625
pubmed: 33654292
PLoS Negl Trop Dis. 2018 Oct 24;12(10):e0006862
pubmed: 30356267
Cell. 2021 Apr 29;184(9):2384-2393.e12
pubmed: 33794143
J Virol. 2006 Oct;80(19):9896-8
pubmed: 16973594
N Engl J Med. 2021 Apr 15;384(15):1412-1423
pubmed: 33626250
N Engl J Med. 2021 Feb 4;384(5):403-416
pubmed: 33378609
N Engl J Med. 2021 Jun 10;384(23):2259-2261
pubmed: 33822494
N Engl J Med. 2021 Jan 7;384(1):80-82
pubmed: 33270381
JAMA. 2021 May 11;325(18):1896-1898
pubmed: 33739374