Monoclonal antibodies block transmission of genetically diverse Plasmodium falciparum strains to mosquitoes.
Journal
NPJ vaccines
ISSN: 2059-0105
Titre abrégé: NPJ Vaccines
Pays: England
ID NLM: 101699863
Informations de publication
Date de publication:
12 08 2021
12 08 2021
Historique:
received:
23
03
2021
accepted:
29
07
2021
entrez:
13
8
2021
pubmed:
14
8
2021
medline:
14
8
2021
Statut:
epublish
Résumé
Malaria parasite transmission to mosquitoes relies on the uptake of sexual stage parasites during a blood meal and subsequent formation of oocysts on the mosquito midgut wall. Transmission-blocking vaccines (TBVs) and monoclonal antibodies (mAbs) target sexual stage antigens to interrupt human-to-mosquito transmission and may form important tools for malaria elimination. Although most epitopes of these antigens are considered highly conserved, little is known about the impact of natural genetic diversity on the functional activity of transmission-blocking antibodies. Here we measured the efficacy of three mAbs against leading TBV candidates (Pfs48/45, Pfs25 and Pfs230) in transmission assays with parasites from naturally infected donors compared to their efficacy against the strain they were raised against (NF54). Transmission-reducing activity (TRA) was measured as reduction in mean oocyst intensity. mAb 45.1 (α-Pfs48/45) and mAb 4B7 (α-Pfs25) reduced transmission of field parasites from almost all donors with IC
Identifiants
pubmed: 34385463
doi: 10.1038/s41541-021-00366-9
pii: 10.1038/s41541-021-00366-9
pmc: PMC8361195
doi:
Types de publication
Journal Article
Langues
eng
Pagination
101Subventions
Organisme : RCUK | Medical Research Council (MRC)
ID : MR/R015600/1
Organisme : RCUK | Medical Research Council (MRC)
ID : MR/R015600/1
Organisme : Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Netherlands Organisation for Scientific Research)
ID : 192.061
Informations de copyright
© 2021. The Author(s).
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