Usefulness of X-ray dark-field imaging in the evaluation of local recurrence after nipple-sparing mastectomy.
Lactiferous ducts
Micro-anatomy
Nipple
Refraction-contrast computed tomography
X-ray dark-field imaging
Journal
International journal of computer assisted radiology and surgery
ISSN: 1861-6429
Titre abrégé: Int J Comput Assist Radiol Surg
Pays: Germany
ID NLM: 101499225
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
14
04
2021
accepted:
02
08
2021
pubmed:
14
8
2021
medline:
17
11
2021
entrez:
13
8
2021
Statut:
ppublish
Résumé
Our previous study suggests that the cross-sectional morphology of ducts and branching of ducts in the nipple are associated with the presence of breast cancer. In this study, we evaluated whether cross-sectional morphology and duct branching of human nipple obtained by X-ray dark-field imaging tomographic technique (XDFI-CT) could predict the likelihood of the presence of intraductal cancer into the nipple. A total of 51 nipple specimens were obtained from consecutive total mastectomies performed for breast cancer in Nagoya Medical Center. After reconstructing 3D images of the nipple using XDFI-CT, the cross-sectional images and the 3D arrangement of ducts were extracted. These cross-sectional images of ducts were classified into four patterns based on the status of the lumen without being informed of pathology results. Of the four patterns, the distended ducts with heterogenous content were highly correlated with the presence of ductal carcinoma in situ confirmed by histopathology. The total number of orifices identified in the 51 specimens was 1298, and 182 (14%) at the tip and 19 (1.5%) at least 5 mm depth from the tip were composed of two or more ducts. Anatomy of nipple ducts is essential to evaluate risk of local recurrence after nipple-sparing mastectomy because cancerous spread occurs within the duct of the same segment of the mammary duct-lobular system in the in situ stage. The 3D microscale anatomy of nipple ducts revealed by XDFI-CT provides useful information to assess the risk of breast cancer involvement at the preserved portion in nipple-sparing mastectomy.
Identifiants
pubmed: 34386901
doi: 10.1007/s11548-021-02472-4
pii: 10.1007/s11548-021-02472-4
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1915-1923Subventions
Organisme : Japanese Ministry of Education, Culture, Sports, Science and Technology
ID : 16K01369
Organisme : Japanese Ministry of Education, Culture, Sports, Science and Technology
ID : 15H01129
Organisme : Japanese Ministry of Education, Culture, Sports, Science and Technology
ID : 26286079
Organisme : Japanese Ministry of Education, Culture, Sports, Science and Technology
ID : 18K13765
Organisme : japanese ministry of education, culture, sports, science and technology
ID : 21K04077
Informations de copyright
© 2021. CARS.
Références
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