Monocyte-to-HDL-cholesterol ratio is associated with Ascending Aorta Dilatation in Patients with Bicuspid Aortic Valve.
Bicuspid aorta
aorta aneurysm
inflammation
monocyte HDL ratio
Journal
African health sciences
ISSN: 1729-0503
Titre abrégé: Afr Health Sci
Pays: Uganda
ID NLM: 101149451
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
entrez:
16
8
2021
pubmed:
17
8
2021
medline:
16
10
2021
Statut:
ppublish
Résumé
The importance of monocyte count-to-HDL-cholesterol ratio (MHR) in cardio- vascular diseases has been shown in various studies. Ascending aortic dilatation (AAD) is a common complication in the patients with bicuspid aortic valve. In this study, we aimed to investigate the relationship between MHR and the presence of aortic dilatation in the patients with bicuspid aortic valve. The study population included totally 347 patients with bicuspid aortic valve.169 patients with aortic dilatation (ascending aorta diameter ≥ 4.0 cm) and 178 patients with no aortic dilatation. Echocardiographic and laboratory measurement was done and compared between groups. The mean age of the participants was 44.7 ± 15.4 years and average ascending aorta diameter was 3.2 ± 0.3 cm in dilatation negative group and 4.4 ± 0.4 cm in positive group. MHR was significantly increased in in patients with aortic dilatation. MHR and uric acid level was independently associated with the presence of aortic dilatation in the patients with bicuspid aortic valve. We found a significant relationship between MHR and aortic dilatation in the patients with bicuspid aortic valve.
Sections du résumé
BACKGROUND
BACKGROUND
The importance of monocyte count-to-HDL-cholesterol ratio (MHR) in cardio- vascular diseases has been shown in various studies. Ascending aortic dilatation (AAD) is a common complication in the patients with bicuspid aortic valve. In this study, we aimed to investigate the relationship between MHR and the presence of aortic dilatation in the patients with bicuspid aortic valve.
METHODS
METHODS
The study population included totally 347 patients with bicuspid aortic valve.169 patients with aortic dilatation (ascending aorta diameter ≥ 4.0 cm) and 178 patients with no aortic dilatation. Echocardiographic and laboratory measurement was done and compared between groups.
RESULTS
RESULTS
The mean age of the participants was 44.7 ± 15.4 years and average ascending aorta diameter was 3.2 ± 0.3 cm in dilatation negative group and 4.4 ± 0.4 cm in positive group. MHR was significantly increased in in patients with aortic dilatation. MHR and uric acid level was independently associated with the presence of aortic dilatation in the patients with bicuspid aortic valve.
CONCLUSION
CONCLUSIONS
We found a significant relationship between MHR and aortic dilatation in the patients with bicuspid aortic valve.
Identifiants
pubmed: 34394286
doi: 10.4314/ahs.v21i1.14
pii: jAFHS.v21.i1.pg96
pmc: PMC8356613
doi:
Substances chimiques
Cholesterol, HDL
0
Cholesterol, LDL
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
96-104Informations de copyright
© 2021 Acar B et al.
Références
Circulation. 2002 Aug 20;106(8):900-4
pubmed: 12186790
Cardiology. 2017;138(1):26-33
pubmed: 28554182
Cardiol Res Pract. 2012;2012:145202
pubmed: 23198270
Circulation. 2005 Mar 29;111(12):1543-50
pubmed: 15781735
Biomark Med. 2015;9(10):967-77
pubmed: 26439248
Clin Appl Thromb Hemost. 2016 Jul;22(5):476-82
pubmed: 26139836
Am J Cardiol. 2007 Mar 1;99(5):686-90
pubmed: 17317372
Acta Cardiol Sin. 2018 Jan;34(1):23-30
pubmed: 29375221
Int J Cardiovasc Imaging. 2005 Apr-Jun;21(2-3):213-7
pubmed: 16015430
J Zhejiang Univ Sci B. 2010 Aug;11(8):592-8
pubmed: 20669349
J Am Coll Cardiol. 2013 Oct 22;62(17):1541-51
pubmed: 23973684
J Thorac Cardiovasc Surg. 2017 Nov;154(5):1764-1765
pubmed: 28689786
Cell Tissue Res. 1979 Apr 12;197(3):379-96
pubmed: 455405
Clin Exp Pharmacol Physiol. 2010 Jul;37(7):710-8
pubmed: 19930423
Biochemistry (Mosc). 2001 Mar;66(3):300-4
pubmed: 11333154
Int Urol Nephrol. 2014 Aug;46(8):1619-25
pubmed: 24853998
Science. 2010 Jun 25;328(5986):1689-93
pubmed: 20488992
Am J Cardiol. 2015 Dec 1;116(11):1685-9
pubmed: 26434515
N Engl J Med. 2014 May 15;370(20):1920-9
pubmed: 24827036
Gen Thorac Cardiovasc Surg. 2015 Sep;63(9):502-6
pubmed: 26033769
J Hypertens. 2013 Jan;31(1):109-16
pubmed: 23221933
Heart Vessels. 2016 May;31(5):795-806
pubmed: 26129868
JAMA. 2008 Sep 17;300(11):1317-25
pubmed: 18799444
Int J Cardiol. 1993 Dec 31;42(3):217-23
pubmed: 8138329
J Am Soc Echocardiogr. 2015 Feb;28(2):119-82
pubmed: 25623219
J Heart Valve Dis. 2016 Sep;25(5):568-573
pubmed: 28238238
J Rheumatol. 2007 Sep;34(9):1882-7
pubmed: 17696269
J Am Coll Cardiol. 2002 Jun 19;39(12):1890-900
pubmed: 12084585
Circ Cardiovasc Imaging. 2013 Jul;6(4):499-507
pubmed: 23771987
Int J Med Sci. 2013;10(2):176-82
pubmed: 23329890
Turk J Med Sci. 2016 Jun 23;46(4):1144-50
pubmed: 27513417
Oxid Med Cell Longev. 2016;2016:5698931
pubmed: 26881031
JAMA. 2011 Sep 14;306(10):1104-12
pubmed: 21917581
J Am Coll Cardiol. 2009 Jun 16;53(24):2288-95
pubmed: 19520254
Circulation. 2011 Feb 1;123(4):e18-e209
pubmed: 21160056
Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):6993-7
pubmed: 1495991
Am J Cardiol. 2003 Aug 1;92(3):275-9
pubmed: 12888130
Eur Heart J. 2014 Nov 1;35(41):2873-926
pubmed: 25173340
Heart. 2002 Oct;88(4):348-51
pubmed: 12231589
Acta Cardiol Sin. 2017 Jan;33(1):41-49
pubmed: 28115806
Biomark Med. 2016 Oct;10(10):1039-1047
pubmed: 27626503
J Thorac Cardiovasc Surg. 2017 Nov;154(5):1756-1762
pubmed: 28651938
Nat Rev Cardiol. 2011 Apr;8(4):222-32
pubmed: 21304474