LiquidCNA: Tracking subclonal evolution from longitudinal liquid biopsies using somatic copy number alterations.
Cancer
Cancer systems biology
Genomics
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
20 Aug 2021
20 Aug 2021
Historique:
received:
20
04
2021
revised:
10
06
2021
accepted:
15
07
2021
entrez:
17
8
2021
pubmed:
18
8
2021
medline:
18
8
2021
Statut:
epublish
Résumé
Cell-free DNA (cfDNA) measured via liquid biopsies provides a way for minimally invasive monitoring of tumor evolutionary dynamics during therapy. Here we present liquidCNA, a method to track subclonal evolution from longitudinally collected cfDNA samples sequenced through cost-effective low-pass whole-genome sequencing. LiquidCNA utilizes somatic copy number alteration (SCNA) to simultaneously genotype and quantify the size of the dominant subclone without requiring B-allele frequency information, matched-normal samples, or prior knowledge on the genetic identity of the emerging clone. We demonstrate the accuracy of liquidCNA in synthetically generated sample sets and
Identifiants
pubmed: 34401670
doi: 10.1016/j.isci.2021.102889
pii: S2589-0042(21)00857-9
pmc: PMC8350516
doi:
Types de publication
Journal Article
Langues
eng
Pagination
102889Subventions
Organisme : Wellcome Trust
ID : 202778/Z/16/Z
Pays : United Kingdom
Organisme : Cancer Research UK
ID : A19771
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : U54 CA217376
Pays : United States
Informations de copyright
© 2021 The Authors.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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