An innovation in stem cell harvesting: Heparin use.
Adult
Aged
Antigens, CD34
/ biosynthesis
Benzylamines
/ administration & dosage
Bone Marrow Transplantation
Chemokine CXCL12
/ biosynthesis
Cyclams
/ administration & dosage
Diffusion of Innovation
Female
Granulocyte Colony-Stimulating Factor
/ administration & dosage
Hematopoietic Stem Cell Mobilization
/ instrumentation
Heparin
/ therapeutic use
Humans
Lymphoma
/ therapy
Male
Middle Aged
Multiple Myeloma
/ therapy
Peripheral Blood Stem Cell Transplantation
/ methods
Receptors, CXCR4
/ biosynthesis
Retrospective Studies
Stem Cells
/ cytology
Young Adult
G-CSF
Heparin
Mobilization
Plerixafor
Stem cell harvesting
Journal
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
ISSN: 1473-0502
Titre abrégé: Transfus Apher Sci
Pays: England
ID NLM: 101095653
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
pubmed:
19
8
2021
medline:
22
2
2022
entrez:
18
8
2021
Statut:
ppublish
Résumé
Stem cell transplantation is a growing treatment strategy for most malignant and non- malignant hematological diseases. Plerixafor and granulocyte colony stimulating factor (G-CSF) are usually used in mobilization regimens to increase the CD34 We administered 5000 units of unfractioned heparin intravenously in 150 mL (mL) of isotonic sodium chloride solution, 15 min before the stem cell harvesting procedure to 141 patients who underwent bone marrow transplantation between the years of 2018 and 2019 at our Stem Cell Transplantation Unit. Thirty patients were included as a control group, and they were not given heparin. The study population included patients with multiple myeloma and lymphoma equally in each group. In all patients hematopoeitic stem cells were successfully harvested in a single cycle of apheresis. In multiple myeloma patients who received heparin, the mean collected CD34 Our results have shown that heparin increases harvested stem cell numbers significantly. Heparin may be a promising agent for stem cell harvesting.
Sections du résumé
BACKGROUND AND OBJECTIVES
OBJECTIVE
Stem cell transplantation is a growing treatment strategy for most malignant and non- malignant hematological diseases. Plerixafor and granulocyte colony stimulating factor (G-CSF) are usually used in mobilization regimens to increase the CD34
MATERIALS AND METHODS
METHODS
We administered 5000 units of unfractioned heparin intravenously in 150 mL (mL) of isotonic sodium chloride solution, 15 min before the stem cell harvesting procedure to 141 patients who underwent bone marrow transplantation between the years of 2018 and 2019 at our Stem Cell Transplantation Unit. Thirty patients were included as a control group, and they were not given heparin. The study population included patients with multiple myeloma and lymphoma equally in each group.
RESULTS
RESULTS
In all patients hematopoeitic stem cells were successfully harvested in a single cycle of apheresis. In multiple myeloma patients who received heparin, the mean collected CD34
CONCLUSIONS
CONCLUSIONS
Our results have shown that heparin increases harvested stem cell numbers significantly. Heparin may be a promising agent for stem cell harvesting.
Identifiants
pubmed: 34404617
pii: S1473-0502(21)00232-9
doi: 10.1016/j.transci.2021.103240
pii:
doi:
Substances chimiques
Antigens, CD34
0
Benzylamines
0
CXCL12 protein, human
0
CXCR4 protein, human
0
Chemokine CXCL12
0
Cyclams
0
Receptors, CXCR4
0
Granulocyte Colony-Stimulating Factor
143011-72-7
Heparin
9005-49-6
plerixafor
S915P5499N
Types de publication
Journal Article
Langues
eng
Pagination
103240Informations de copyright
Copyright © 2021. Published by Elsevier Ltd.