Endothelial-Mesenchymal Transition in Heart Failure With a Preserved Ejection Fraction: Insights Into the Cardiorenal Syndrome.
cardio-renal syndrome
diastolic
fibrosis
heart failure
Journal
Circulation. Heart failure
ISSN: 1941-3297
Titre abrégé: Circ Heart Fail
Pays: United States
ID NLM: 101479941
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
pubmed:
20
8
2021
medline:
24
12
2021
entrez:
19
8
2021
Statut:
ppublish
Résumé
The management of clinical heart failure with a preserved ejection fraction (HFpEF) is often complicated by concurrent renal dysfunction, known as the cardiorenal syndrome. This, combined with the notable lack of evidence-based therapies for HFpEF, highlights the importance of examining mechanisms and targetable pathways in HFpEF with the cardiorenal syndrome. HFpEF was induced in mice by uninephrectomy, infusion of Kidneys from HFpEF mice demonstrated hypertrophy, interstitial fibrosis (1.9-fold increase; These translational findings demonstrate a plausible role for endo-MT in HFpEF with cardiorenal syndrome and may have therapeutic implications in drug development for patients with HFpEF and concomitant renal dysfunction.
Sections du résumé
BACKGROUND
The management of clinical heart failure with a preserved ejection fraction (HFpEF) is often complicated by concurrent renal dysfunction, known as the cardiorenal syndrome. This, combined with the notable lack of evidence-based therapies for HFpEF, highlights the importance of examining mechanisms and targetable pathways in HFpEF with the cardiorenal syndrome.
METHODS
HFpEF was induced in mice by uninephrectomy, infusion of
RESULTS
Kidneys from HFpEF mice demonstrated hypertrophy, interstitial fibrosis (1.9-fold increase;
CONCLUSIONS
These translational findings demonstrate a plausible role for endo-MT in HFpEF with cardiorenal syndrome and may have therapeutic implications in drug development for patients with HFpEF and concomitant renal dysfunction.
Identifiants
pubmed: 34407636
doi: 10.1161/CIRCHEARTFAILURE.121.008372
pmc: PMC8575120
mid: NIHMS1728876
doi:
Substances chimiques
Biomarkers
0
Aldosterone
4964P6T9RB
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e008372Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL145985
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007224
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL125232
Pays : United States
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