Effects of the Norfolk diabetes prevention lifestyle intervention (NDPS) on glycaemic control in screen-detected type 2 diabetes: a randomised controlled trial.
Diabetes Prevention Mentors
Glycaemic control
Lifestyle Intervention
Peer support
Screen detected
Type 2 diabetes
Journal
BMC medicine
ISSN: 1741-7015
Titre abrégé: BMC Med
Pays: England
ID NLM: 101190723
Informations de publication
Date de publication:
19 08 2021
19 08 2021
Historique:
received:
09
03
2021
accepted:
06
07
2021
entrez:
19
8
2021
pubmed:
20
8
2021
medline:
21
10
2021
Statut:
epublish
Résumé
The purpose of this trial was to test if the Norfolk Diabetes Prevention Study (NDPS) lifestyle intervention, recently shown to reduce the incidence of type 2 diabetes in high-risk groups, also improved glycaemic control in people with newly diagnosed screen-detected type 2 diabetes. We screened 12,778 participants at high risk of type 2 diabetes using a fasting plasma glucose and glycosylated haemoglobin (HbA1c). People with screen-detected type 2 diabetes were randomised in a parallel, three-arm, controlled trial with up to 46 months of follow-up, with a control arm (CON), a group-based lifestyle intervention of 6 core and up to 15 maintenance sessions (INT), or the same intervention with additional support from volunteers with type 2 diabetes trained to co-deliver the lifestyle intervention (INT-DPM). The pre-specified primary end point was mean HbA1c compared between groups at 12 months. We randomised 432 participants (CON 149; INT 142; INT-DPM 141) with a mean (SD) age of 63.5 (10.0) years, body mass index (BMI) of 32.4 (6.4) kg/m The NDPS lifestyle intervention significantly improved glycaemic control after 12 months in people with screen-detected type 2 diabetes when supported by trained peer mentors with type 2 diabetes, particularly those receiving oral hypoglycaemics and those under 65 years old. The effect size was modest, however, and not sustained at 24 months. ISRCTN34805606 . Retrospectively registered 14.4.16.
Sections du résumé
BACKGROUND
The purpose of this trial was to test if the Norfolk Diabetes Prevention Study (NDPS) lifestyle intervention, recently shown to reduce the incidence of type 2 diabetes in high-risk groups, also improved glycaemic control in people with newly diagnosed screen-detected type 2 diabetes.
METHODS
We screened 12,778 participants at high risk of type 2 diabetes using a fasting plasma glucose and glycosylated haemoglobin (HbA1c). People with screen-detected type 2 diabetes were randomised in a parallel, three-arm, controlled trial with up to 46 months of follow-up, with a control arm (CON), a group-based lifestyle intervention of 6 core and up to 15 maintenance sessions (INT), or the same intervention with additional support from volunteers with type 2 diabetes trained to co-deliver the lifestyle intervention (INT-DPM). The pre-specified primary end point was mean HbA1c compared between groups at 12 months.
RESULTS
We randomised 432 participants (CON 149; INT 142; INT-DPM 141) with a mean (SD) age of 63.5 (10.0) years, body mass index (BMI) of 32.4 (6.4) kg/m
CONCLUSION
The NDPS lifestyle intervention significantly improved glycaemic control after 12 months in people with screen-detected type 2 diabetes when supported by trained peer mentors with type 2 diabetes, particularly those receiving oral hypoglycaemics and those under 65 years old. The effect size was modest, however, and not sustained at 24 months.
TRIAL REGISTRATION
ISRCTN34805606 . Retrospectively registered 14.4.16.
Identifiants
pubmed: 34407811
doi: 10.1186/s12916-021-02053-x
pii: 10.1186/s12916-021-02053-x
pmc: PMC8375190
doi:
Substances chimiques
Blood Glucose
0
Eye Proteins
0
Glycated Hemoglobin A
0
Hypoglycemic Agents
0
NDP protein, human
0
Nerve Tissue Proteins
0
Banques de données
ISRCTN
['ISRCTN34805606']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
183Investigateurs
Sara Auckland
(S)
Max Bachmann
(M)
Garry Barton
(G)
Allan Clark
(A)
Ketan Dhatariya
(K)
Clare Ferns
(C)
Nikki Garner
(N)
Colin Greaves
(C)
Andy Goldson
(A)
Martin Hadley-Brown
(M)
Amanda Howe
(A)
Lisa Irvine
(L)
Garry John
(G)
Melanie Pascale
(M)
David Rea
(D)
Jane Smith
(J)
Jeremy Turner Rebecca Usher
(JTR)
Tara Wallace
(T)
Informations de copyright
© 2021. The Author(s).
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