X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19.


Journal

Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624

Informations de publication

Date de publication:
19 08 2021
Historique:
received: 13 07 2021
accepted: 12 08 2021
entrez: 20 8 2021
pubmed: 21 8 2021
medline: 27 8 2021
Statut: ppublish

Résumé

Autosomal inborn errors of type I IFN immunity and autoantibodies against these cytokines underlie at least 10% of critical COVID-19 pneumonia cases. We report very rare, biochemically deleterious X-linked

Identifiants

pubmed: 34413140
pii: 6/62/eabl4348
doi: 10.1126/sciimmunol.abl4348
pmc: PMC8532080
mid: NIHMS1744435
pii:
doi:

Substances chimiques

TLR7 protein, human 0
Toll-Like Receptor 7 0

Types de publication

Journal Article Observational Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NHGRI NIH HHS
ID : UM1 HG006504
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA AI001270
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI088364
Pays : United States
Organisme : Medical Research Council
ID : MR/S032304/1
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI163029
Pays : United States
Organisme : Intramural NIH HHS
ID : 1Z1 AA1001265
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001866
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA AI001265
Pays : United States
Organisme : NHGRI NIH HHS
ID : U24 HG008956
Pays : United States

Investigateurs

Laurent Abel (L)
Alessandro Aiuti (A)
Saleh Al-Muhsen (S)
Fahd Al-Mulla (F)
Mark S Anderson (MS)
Evangelos Andreakos (E)
Andrés A Arias (AA)
Hagit Baris Feldman (HB)
Alexandre Belot (A)
Catherine M Biggs (CM)
Dusan Bogunovic (D)
Alexandre Bolze (A)
Anastasiia Bondarenko (A)
Ahmed A Bousfiha (AA)
Petter Brodin (P)
Yenan Bryceson (Y)
Carlos D Bustamante (CD)
Manish J Butte (MJ)
Giorgio Casari (G)
Samya Chakravorty (S)
John Christodoulou (J)
Antonio Condino-Neto (A)
Stefan N Constantinescu (SN)
Megan A Cooper (MA)
Clifton L Dalgard (CL)
Murkesh Desai (M)
Beth A Drolet (BA)
Jamila El Baghdadi (J)
Sara Espinosa-Padilla (S)
Jacques Fellay (J)
Carlos Flores (C)
José Luis Franco (JL)
Antoine Froidure (A)
Peter K Gregersen (PK)
Filomeen Haerynck (F)
David Hagin (D)
Rabih Halwani (R)
Lennart Hammarström (L)
James R Heath (JR)
Sarah E Henrickson (SE)
Elena W Y Hsieh (EWY)
Eystein Husebye (E)
Kohsuke Imai (K)
Yuval Itan (Y)
Erich D Jarvis (ED)
Timokratis Karamitros (T)
Kai Kisand (K)
Cheng-Lung Ku (CL)
Yu-Lung Lau (YL)
Yun Ling (Y)
Carrie L Lucas (CL)
Tom Maniatis (T)
Davood Mansouri (D)
László Maródi (L)
Isabelle Meyts (I)
Joshua D Milner (JD)
Kristina Mironska (K)
Trine H Mogensen (TH)
Tomohiro Morio (T)
Lisa F P Ng (LFP)
Luigi D Notarangelo (LD)
Antonio Novelli (A)
Giuseppe Novelli (G)
Cliona O'Farrelly (C)
Satoshi Okada (S)
Tayfun Ozcelik (T)
Qiang Pan-Hammarström (Q)
Rebeca Perez de Diego (RP)
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Mohammed Shahrooei (M)
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Andrew L Snow (AL)
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Elisabeth Botelho-Nevers (E)
Christelle Kouakam (C)
Nicolas Leturque (N)
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Miranda F Tompkins (MF)
Camille Alba (C)
Andrew L Snow (AL)
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John Rosenberger (J)
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Xijun Zhang (X)
Justin Lack (J)
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Virginia Quaresima (V)
Eugenia Quiros-Roldan (E)
Camillo Rossi (C)

Informations de copyright

Copyright © 2021, American Association for the Advancement of Science.

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Auteurs

Takaki Asano (T)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.

Bertrand Boisson (B)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. casanova@rockefeller.edu bebo283@rockefeller.edu.
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
University of Paris, Imagine Institute, Paris, France.

Fanny Onodi (F)

Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR7212, University of Paris, Research Institute of Saint-Louis, Saint-Louis Hospital, Paris, France.

Daniela Matuozzo (D)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
University of Paris, Imagine Institute, Paris, France.

Marcela Moncada-Velez (M)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.

Majistor Raj Luxman Maglorius Renkilaraj (MRL)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
University of Paris, Imagine Institute, Paris, France.

Peng Zhang (P)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.

Laurent Meertens (L)

Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR7212, University of Paris, Research Institute of Saint-Louis, Saint-Louis Hospital, Paris, France.

Alexandre Bolze (A)

Helix, San Mateo, CA, USA.

Marie Materna (M)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
University of Paris, Imagine Institute, Paris, France.

Sarantis Korniotis (S)

University of Paris, INSERM U976, F-75006 Paris, France.

Adrian Gervais (A)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
University of Paris, Imagine Institute, Paris, France.

Estelle Talouarn (E)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
University of Paris, Imagine Institute, Paris, France.

Benedetta Bigio (B)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.

Yoann Seeleuthner (Y)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
University of Paris, Imagine Institute, Paris, France.

Kaya Bilguvar (K)

Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA.

Yu Zhang (Y)

Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA.
NIAID Clinical Genomics Program, NIH, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA.

Anna-Lena Neehus (AL)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
University of Paris, Imagine Institute, Paris, France.

Masato Ogishi (M)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.

Simon J Pelham (SJ)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.

Tom Le Voyer (T)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
University of Paris, Imagine Institute, Paris, France.

Jérémie Rosain (J)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
University of Paris, Imagine Institute, Paris, France.

Quentin Philippot (Q)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
University of Paris, Imagine Institute, Paris, France.

Pere Soler-Palacín (P)

Infection in Immunocompromised Pediatric Patients Research Group, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron University Hospital (HUVH), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Catalonia Spain.
Pediatric Infectious Diseases and Immunodeficiencies Unit, Vall d'Hebron University Hospital (HUVH), Vall d'Hebron Research Institute (VHIR), Vall d'Hebron Barcelona Hospital Campus, Autonomous University of Barcelona (UAB), Barcelona, Catalonia, Spain.
Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, Barcelona, Catalonia, Spain.

Roger Colobran (R)

Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, Barcelona, Catalonia, Spain.
Diagnostic Immunology Group, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron University Hospital (HUVH), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Catalonia, Spain.
Immunology Division, Genetics Department, Vall d'Hebron University Hospital (HUVH), Vall d'Hebron Barcelona Hospital Campus, Autonomous University of Barcelona (UAB), Barcelona, Catalonia, Spain.

Andrea Martin-Nalda (A)

Infection in Immunocompromised Pediatric Patients Research Group, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron University Hospital (HUVH), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Catalonia Spain.
Pediatric Infectious Diseases and Immunodeficiencies Unit, Vall d'Hebron University Hospital (HUVH), Vall d'Hebron Research Institute (VHIR), Vall d'Hebron Barcelona Hospital Campus, Autonomous University of Barcelona (UAB), Barcelona, Catalonia, Spain.
Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, Barcelona, Catalonia, Spain.

Jacques G Rivière (JG)

Infection in Immunocompromised Pediatric Patients Research Group, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron University Hospital (HUVH), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Catalonia Spain.
Pediatric Infectious Diseases and Immunodeficiencies Unit, Vall d'Hebron University Hospital (HUVH), Vall d'Hebron Research Institute (VHIR), Vall d'Hebron Barcelona Hospital Campus, Autonomous University of Barcelona (UAB), Barcelona, Catalonia, Spain.
Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, Barcelona, Catalonia, Spain.

Yacine Tandjaoui-Lambiotte (Y)

AP-HP, Avicenne Hospital, Intensive Care Unit, Bobigny, France.
INSERM U1272 Hypoxia & Lung, Bobigny, France.

Khalil Chaïbi (K)

Anesthesiology and Critical Care Medicine Department, APHP, Avicenne Hospital, Bobigny, France.
Common and Rare Kidney Diseases, Sorbonne University, INSERM UMR-S 1155, Paris, France.

Mohammad Shahrooei (M)

Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran.
Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium.

Ilad Alavi Darazam (IA)

Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Infectious Diseases and Tropical Medicine, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Nasrin Alipour Olyaei (NA)

Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran.
Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium.

Davood Mansouri (D)

Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran.
Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran.

Nevin Hatipoğlu (N)

Pediatric Infectious Diseases Unit, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

Figen Palabiyik (F)

Pediatric Infectious Diseases Unit, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

Tayfun Ozcelik (T)

Department of Molecular Biology and Genetics, University of Bilkent, Bilkent-Ankara, Turkey.

Giuseppe Novelli (G)

Department of Biomedicine and Prevention, University of Rome "Tor Vergata," Rome, and Neuromed Institute, IRCCS, Pozzilli (IS), Italy.

Antonio Novelli (A)

Laboratory of Medical Genetics, Translational Cytogenomics Research Unit, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.

Giorgio Casari (G)

Vita-Salute San Raffaele University, Milan, Italy.
Clinical Genomics, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Alessandro Aiuti (A)

Vita-Salute San Raffaele University, Milan, Italy.
San Raffaele Telethon Institute for Gene Therapy (SR-Tiget) and Pediatric Immunohematology Unit and BMT Program, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Paola Carrera (P)

Clinical Genomics, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Simone Bondesan (S)

Clinical Genomics, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Federica Barzaghi (F)

San Raffaele Telethon Institute for Gene Therapy (SR-Tiget) and Pediatric Immunohematology Unit and BMT Program, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Patrizia Rovere-Querini (P)

Vita-Salute San Raffaele University, Milan, Italy.
Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Cristina Tresoldi (C)

Molecular Hematology Unit, IRCCS Ospedale San Raffaele, Milan, Italy.

Jose Luis Franco (JL)

Primary Immunodeficiencies Group, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.

Julian Rojas (J)

Primary Immunodeficiencies Group, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.

Luis Felipe Reyes (LF)

Universidad de La Sabana, Chia, Colombia.

Ingrid G Bustos (IG)

Universidad de La Sabana, Chia, Colombia.

Andres Augusto Arias (AA)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Primary Immunodeficiencies Group, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
School of Microbiology, University of Antioquia UdeA, Medellín, Colombia.

Guillaume Morelle (G)

Department of General Pediatrics, Hôpital Bicêtre, AP-HP, University of Paris Saclay, Le Kremlin-Bicêtre, France.

Kyheng Christèle (K)

Department of General Pediatrics, Hôpital Bicêtre, AP-HP, University of Paris Saclay, Le Kremlin-Bicêtre, France.

Jesús Troya (J)

Department of Internal Medicine, Infanta Leonor University Hospital, Madrid, Spain.

Laura Planas-Serra (L)

Neurometabolic Diseases Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
Center for Biomedical Research on Rare Diseases (CIBERER), ISCIII, Spain.

Agatha Schlüter (A)

Neurometabolic Diseases Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
Center for Biomedical Research on Rare Diseases (CIBERER), ISCIII, Spain.

Marta Gut (M)

CNAG-CRG, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Baldiri Reixac 4, 08028, Barcelona, Spain.

Aurora Pujol (A)

Neurometabolic Diseases Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
Center for Biomedical Research on Rare Diseases (CIBERER), ISCIII, Spain.
Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain.

Luis M Allende (LM)

Immunology Department, University Hospital 12 de Octubre, Research Institute Hospital 12 de Octubre (I+12), Madrid, Spain.
Complutense University, Madrid, Spain.

Carlos Rodriguez-Gallego (C)

Department of Immunology, University Hospital of Gran Canaria Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain.
Department of Clinical Sciences, University of Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain.

Carlos Flores (C)

Genomics Division, Institute of Technology and Renewable Energies (ITER), Santa Cruz de Tenerife, Spain.
CIBER de Enfermedades Respiratorias, Health Institute of Carlos III, Madrid, Spain.
Research Unit, University Hospital of N.S. de Candelaria, Santa Cruz de Tenerife, Spain.
Institute of Biomedical technologies (ITB), University of La Laguna, San Cristóbal de La Laguna, Spain.

Oscar Cabrera-Marante (O)

Immunology Department, University Hospital 12 de Octubre, Research Institute Hospital 12 de Octubre (I+12), Madrid, Spain.

Daniel E Pleguezuelo (DE)

Immunology Department, University Hospital 12 de Octubre, Research Institute Hospital 12 de Octubre (I+12), Madrid, Spain.

Rebeca Pérez de Diego (RP)

Institute of Biomedical Research of IdiPAZ, University Hospital "La Paz", Madrid, Spain.

Sevgi Keles (S)

Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey.

Gokhan Aytekin (G)

Konya City Hospital, Division of Allergy and Immunology, Konya, Turkey.

Ozge Metin Akcan (OM)

Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey.

Yenan T Bryceson (YT)

Centre for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institute, Stockholm, Sweden.

Peter Bergman (P)

Department of Laboratory Medicine, Division of Clinical Microbiology, Karolinska Institute, Stockholm, Sweden.
The Immunodeficiency Unit, Infectious Disease Clinic, Karolinska University Hospital, Stockholm, Sweden.

Petter Brodin (P)

Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institute, Solna, Sweden.

Daniel Smole (D)

Central Hospital-Anesthesia and Intensive Care Unit, Karlstad, Sweden.

C I Edvard Smith (CIE)

Department of Laboratory Medicine, Division of Biomolecular and Cellular Medicine, Karolinska Institute, Stockholm, Sweden.
The Immunodeficiency Unit, Infectious Disease Clinic, Karolinska University Hospital, Stockholm, Sweden.

Anna-Carin Norlin (AC)

The Immunodeficiency Unit, Infectious Disease Clinic, Karolinska University Hospital, Stockholm, Sweden.

Tessa M Campbell (TM)

Centre for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institute, Stockholm, Sweden.

Laura E Covill (LE)

Centre for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institute, Stockholm, Sweden.

Lennart Hammarström (L)

Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden.

Qiang Pan-Hammarström (Q)

Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden.

Hassan Abolhassani (H)

Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden.
Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Shrikant Mane (S)

Department of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA.

Nico Marr (N)

Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar.

Manar Ata (M)

Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar.

Fatima Al Ali (F)

Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar.

Taushif Khan (T)

Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar.

András N Spaan (AN)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands.

Clifton L Dalgard (CL)

Department of Anatomy, Physiology & Genetics Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
The American Genome Center, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Paolo Bonfanti (P)

Department of Infectious Diseases, San Gerardo Hospital-University of Milano-Bicocca, Monza, Italy.

Andrea Biondi (A)

Pediatric Department and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM- Ospedale San Gerardo, Monza, Italy.

Sarah Tubiana (S)

Centre d'Investigation Clinique, INSERM CIC 1425, Paris, France.
Hôpital Bichat Claude Bernard, APHP, Paris, France.

Charles Burdet (C)

Centre d'Investigation Clinique, INSERM CIC 1425, Paris, France.
Université de Paris, IAME, INSERM UMR 1137, Paris, France.

Robert Nussbaum (R)

Invitae, San Francisco, CA, USA.

Amanda Kahn-Kirby (A)

Invitae, San Francisco, CA, USA.

Andrew L Snow (AL)

Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Jacinta Bustamante (J)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
University of Paris, Imagine Institute, Paris, France.
Center for the Study of Primary Immunodeficiencies, Necker Hospital for Sick Children, AP-HP, Paris, France, EU.

Anne Puel (A)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
University of Paris, Imagine Institute, Paris, France.

Stéphanie Boisson-Dupuis (S)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
University of Paris, Imagine Institute, Paris, France.

Shen-Ying Zhang (SY)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
University of Paris, Imagine Institute, Paris, France.

Vivien Béziat (V)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
University of Paris, Imagine Institute, Paris, France.

Richard P Lifton (RP)

Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA.
Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA.

Paul Bastard (P)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
University of Paris, Imagine Institute, Paris, France.

Luigi D Notarangelo (LD)

Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA.
NIAID Clinical Genomics Program, NIH, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA.

Laurent Abel (L)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
University of Paris, Imagine Institute, Paris, France.

Helen C Su (HC)

Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA.
NIAID Clinical Genomics Program, NIH, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA.
Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Emmanuelle Jouanguy (E)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
University of Paris, Imagine Institute, Paris, France.

Ali Amara (A)

Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR7212, University of Paris, Research Institute of Saint-Louis, Saint-Louis Hospital, Paris, France.

Vassili Soumelis (V)

University of Paris, INSERM U976, F-75006 Paris, France.
APHP, Hôpital Saint-Louis, Department of Immunology-Histocompatibility, 75010 Paris, France.

Aurélie Cobat (A)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
University of Paris, Imagine Institute, Paris, France.

Qian Zhang (Q)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.

Jean-Laurent Casanova (JL)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. casanova@rockefeller.edu bebo283@rockefeller.edu.
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
University of Paris, Imagine Institute, Paris, France.
Howard Hughes Medical Institute, New York, NY, USA.

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