CD8-Targeted PET Imaging of Tumor-Infiltrating T Cells in Patients with Cancer: A Phase I First-in-Humans Study of
CD8-Positive T-Lymphocytes
Carcinoma, Hepatocellular
Carcinoma, Non-Small-Cell Lung
Cell Line, Tumor
Humans
Liver Neoplasms
Lung Neoplasms
Melanoma
/ diagnostic imaging
Positron Emission Tomography Computed Tomography
/ methods
Positron-Emission Tomography
/ methods
T-Lymphocytes
Tissue Distribution
Tomography, X-Ray Computed
Zirconium
89Zr-Df-IAB22M2C
CD8+ T cell
PET imaging
immunotherapy
minibody
Journal
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
ISSN: 1535-5667
Titre abrégé: J Nucl Med
Pays: United States
ID NLM: 0217410
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
25
04
2021
revised:
05
08
2021
pubmed:
21
8
2021
medline:
4
5
2022
entrez:
20
8
2021
Statut:
ppublish
Résumé
There is a need for in vivo diagnostic imaging probes that can noninvasively measure tumor-infiltrating CD8+ leukocytes. Such imaging probes could be used to predict early response to cancer immunotherapy, help select effective single or combination immunotherapies, and facilitate the development of new immunotherapies or immunotherapy combinations. This study was designed to optimize conditions for performing CD8 PET imaging with
Identifiants
pubmed: 34413145
pii: jnumed.121.262485
doi: 10.2967/jnumed.121.262485
pmc: PMC9051598
doi:
Substances chimiques
Zirconium
C6V6S92N3C
Banques de données
ClinicalTrials.gov
['NCT03107663']
Types de publication
Clinical Trial, Phase I
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
720-726Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Informations de copyright
© 2022 by the Society of Nuclear Medicine and Molecular Imaging.
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