A sex-specific feedback projection from aromatase-expressing neurons in the medial amygdala to the accessory olfactory bulb.
aromatase
feedback
medial amygdala
olfactory
pheromones
vomeronasal
Journal
The Journal of comparative neurology
ISSN: 1096-9861
Titre abrégé: J Comp Neurol
Pays: United States
ID NLM: 0406041
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
revised:
09
08
2021
received:
28
06
2021
accepted:
17
08
2021
pubmed:
21
8
2021
medline:
5
4
2022
entrez:
20
8
2021
Statut:
ppublish
Résumé
The accessory olfactory bulb (AOB) plays a critical role in classifying pheromonal signals. Here we identify two previously undescribed sources of aromatase signaling in the AOB: (1) a population of aromatase-expressing neurons in the AOB itself; (2) a tract of aromatase-expressing axons which originate in the ventral medial amygdala (MEA) and terminate in the AOB. Using a retrograde tracer in conjunction with a transgenic strategy to label aromatase-expressing neurons throughout the brain, we found that a single contiguous population of neurons in the ventral MEA provides the only significant feedback by aromatase-expressing neurons to the AOB. This population expresses the estrogen receptor alpha (ERα) and displayed anatomical sex differences in the number of neurons (higher in male mice) and the size of cell bodies (larger in females). Given the previously established relationship between aromatase expression, estrogen signaling, and the function of sexually dimorphic circuits, we suggest that this feedback population is well-positioned to provide neuroendocrine feedback to modulate sensory processing of social stimuli in the AOB.
Identifiants
pubmed: 34415057
doi: 10.1002/cne.25236
pmc: PMC8716422
mid: NIHMS1734350
doi:
Substances chimiques
Aromatase
EC 1.14.14.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
648-655Subventions
Organisme : NIMH NIH HHS
ID : R01 MH115094
Pays : United States
Organisme : NIMH NIH HHS
ID : R01MH115094-01A1
Pays : United States
Informations de copyright
© 2021 Wiley Periodicals LLC.
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