Murine BST2/tetherin promotes measles virus infection of neurons.
BST2
Measles virus
Neuron
Tetherin
Journal
Virology
ISSN: 1096-0341
Titre abrégé: Virology
Pays: United States
ID NLM: 0110674
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
27
04
2021
revised:
06
08
2021
accepted:
11
08
2021
pubmed:
21
8
2021
medline:
4
1
2022
entrez:
20
8
2021
Statut:
ppublish
Résumé
BST2/tetherin is a transmembrane protein with antiviral activity; it is synthesized following exposure to interferons, and restricts the release of budding virus particles by tethering them to the host cell membrane. We previously showed that BST2 is induced in primary neurons following measles virus (MV) infection or type I interferon; however, BST2 was dispensable for protection against challenge with neuron-restricted MV. Here, we define the contribution of BST-2 in neuronal MV infection. Surprisingly, and in contrast to its antiviral role in non-neuronal cells, murine BST2 promotes MV infection in brains of permissive mice and in primary neuron cultures. Moreover, BST2 expression was predominantly observed in the non-synaptic fraction of purified neurons. These studies highlight a cell-type dependent role of a well-characterized antiviral protein in enhancing neuronal infection.
Identifiants
pubmed: 34416448
pii: S0042-6822(21)00167-7
doi: 10.1016/j.virol.2021.08.005
pmc: PMC8491112
mid: NIHMS1737099
pii:
doi:
Substances chimiques
Antigens, CD
0
BST2 protein, mouse
0
Membrane Glycoproteins
0
RNA, Viral
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
38-43Subventions
Organisme : NINDS NIH HHS
ID : F31 NS092307
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA006927
Pays : United States
Organisme : NINDS NIH HHS
ID : T32 NS007180
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
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