Inactivation of Hedgehog signal transduction in adult astrocytes results in region-specific blood-brain barrier defects.
Animals
Astrocytes
/ metabolism
Blood-Brain Barrier
/ metabolism
Brain
/ drug effects
Gene Expression Regulation
/ drug effects
Gliosis
/ metabolism
Hedgehog Proteins
/ genetics
Mice
Mice, Transgenic
Selective Estrogen Receptor Modulators
/ pharmacology
Smoothened Receptor
/ genetics
Spinal Cord
/ drug effects
Tamoxifen
/ pharmacology
Veratrum Alkaloids
/ pharmacology
albumin extravasation
astrocyte
blood–brain barrier
sonic hedgehog
transcytosis
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
24 08 2021
24 08 2021
Historique:
entrez:
21
8
2021
pubmed:
22
8
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
In this study, we use molecular genetic approaches to clarify the role of the Hedgehog (Hh) pathway in regulating the blood-brain/spinal cord barrier (BBB) in the adult mouse central nervous system (CNS). Our work confirms and extends prior studies to demonstrate that astrocytes are the predominant cell type in the adult CNS that transduce Hh signaling, revealed by the expression of
Identifiants
pubmed: 34417306
pii: 2017779118
doi: 10.1073/pnas.2017779118
pmc: PMC8403837
pii:
doi:
Substances chimiques
Hedgehog Proteins
0
Selective Estrogen Receptor Modulators
0
Smo protein, mouse
0
Smoothened Receptor
0
Veratrum Alkaloids
0
Tamoxifen
094ZI81Y45
cyclopamine
ZH658AJ192
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no competing interest.
Références
Nature. 2018 Feb 22;554(7693):475-480
pubmed: 29443965
Int J Mol Sci. 2019 Jan 29;20(3):
pubmed: 30699952
Nature. 2017 Jan 26;541(7638):481-487
pubmed: 28099414
Dev Cell. 2006 May;10(5):647-56
pubmed: 16647304
J Neurosci. 2010 Oct 13;30(41):13597-608
pubmed: 20943901
Nat Rev Neurosci. 2015 May;16(5):249-63
pubmed: 25891508
J Neurosci. 2006 Aug 16;26(33):8609-21
pubmed: 16914687
Development. 2002 Oct;129(20):4753-61
pubmed: 12361967
Semin Immunopathol. 2015 Nov;37(6):577-90
pubmed: 26245144
Science. 2011 Dec 23;334(6063):1727-31
pubmed: 22144466
Genes Dev. 2007 May 15;21(10):1244-57
pubmed: 17504941
Exp Neurobiol. 2018 Dec;27(6):508-525
pubmed: 30636902
Dev Cell. 2004 Jan;6(1):103-15
pubmed: 14723851
J Neurosci. 2014 Sep 3;34(36):11929-47
pubmed: 25186741
Cell. 2018 Aug 9;174(4):999-1014.e22
pubmed: 30096314
Biochim Biophys Acta. 2016 Mar;1862(3):483-91
pubmed: 26655603
Mech Dev. 2015 Nov;138 Pt 1:8-16
pubmed: 26215350
Nat Neurosci. 2008 Mar;11(3):277-84
pubmed: 18297065
Cancers (Basel). 2016 Feb 15;8(2):
pubmed: 26891329
Genes Dev. 2002 Nov 1;16(21):2743-8
pubmed: 12414725
Development. 2005 Jan;132(2):335-44
pubmed: 15604099
Neuron. 2016 Dec 21;92(6):1181-1195
pubmed: 27939582
Development. 2000 Apr;127(8):1593-605
pubmed: 10725236
J Neurosci. 2012 May 2;32(18):6391-410
pubmed: 22553043
J Neurosci. 2008 Jan 2;28(1):264-78
pubmed: 18171944
Ann Neurol. 2012 Nov;72(5):648-72
pubmed: 23280789
Nat Rev Neurosci. 2006 Jan;7(1):41-53
pubmed: 16371949
Development. 2020 May 1;147(9):
pubmed: 32358096
Cold Spring Harb Perspect Biol. 2015 Jan 05;7(1):a020412
pubmed: 25561720
Immunity. 2017 Jun 20;46(6):957-967
pubmed: 28636962
J Neurosci. 2017 Sep 6;37(36):8706-8717
pubmed: 28821665
Front Cell Neurosci. 2014 Aug 04;8:211
pubmed: 25136294
J Exp Med. 2020 Apr 6;217(4):
pubmed: 32211826
Cell Rep. 2018 Jan 2;22(1):269-285
pubmed: 29298427
Sci Rep. 2019 Jan 24;9(1):565
pubmed: 30679745
Development. 2001 Dec;128(24):5099-108
pubmed: 11748145
Physiol Rev. 2019 Jan 1;99(1):21-78
pubmed: 30280653
Science. 2016 Feb 19;351(6275):849-54
pubmed: 26912893
Neuron. 2014 Jan 22;81(2):229-48
pubmed: 24462092
J Cell Biol. 2008 Nov 3;183(3):371-3
pubmed: 18955557
Methods Mol Biol. 2015;1322:81-92
pubmed: 26179041
Development. 2004 Aug;131(15):3593-604
pubmed: 15215207
Brain Plast. 2018 Aug 10;3(2):119-128
pubmed: 30151337
Acta Neuropathol. 2018 Mar;135(3):311-336
pubmed: 29411111
Glia. 2019 Jan;67(1):171-181
pubmed: 30430665
Nat Med. 2013 Dec;19(12):1584-96
pubmed: 24309662
Semin Cell Dev Biol. 2014 Sep;33:105-11
pubmed: 24862855
Cell. 2004 Aug 20;118(4):505-16
pubmed: 15315762