Mesenchymal stem cell transfusion: Possible beneficial effects in COVID-19 patients.
COVID-19
/ blood
Disseminated Intravascular Coagulation
/ blood
Humans
Lung
/ physiology
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells
/ metabolism
Peptidyl-Dipeptidase A
/ metabolism
Prospective Studies
Regeneration
Risk Factors
SARS-CoV-2
/ metabolism
Thromboembolism
/ blood
Thromboplastin
/ biosynthesis
COVID-19
Mesenchymal stem cell
SARS-CoV-2
Transfusion
Transplantation
Journal
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
ISSN: 1473-0502
Titre abrégé: Transfus Apher Sci
Pays: England
ID NLM: 101095653
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
17
12
2020
revised:
15
07
2021
accepted:
08
08
2021
pubmed:
23
8
2021
medline:
21
12
2021
entrez:
22
8
2021
Statut:
ppublish
Résumé
SARS-CoV-2 attaches to the angiotensin-converting enzyme 2 (ACE-2) receptor on human cells. The virus causes hypercytokinemia, capillary leak, pulmonary edema, acute respiratory distress syndrome, acute cardiac injury, and leads to death. Mesenchymal stem cells (MSCs) are ACE-2 negative cells; therefore, can escape from SARS-CoV-2. MSCs prevent hypercytokinemia and help the resolution of the pulmonary edema and other damages occurred during the course of COVID-19. In addition, MSCs enhance the regeneration of the lung and other tissues affected by SARS-CoV-2. The case series reported beneficial effect of MSCs in COVID-19 treatment. However, there are some concerns about the safety of MSCs, particularly referring to the increased risk of disseminated intravascular coagulation, and thromboembolism due to the expression of TF/CD142. Prospective, randomized, large scale studies are needed to reveal the optimum dose, administration way, time, efficacy, and safety of MSCs in the COVID-19 treatment.
Identifiants
pubmed: 34419356
pii: S1473-0502(21)00229-9
doi: 10.1016/j.transci.2021.103237
pmc: PMC8372452
pii:
doi:
Substances chimiques
Thromboplastin
9035-58-9
ACE protein, human
EC 3.4.15.1
Peptidyl-Dipeptidase A
EC 3.4.15.1
Types de publication
Journal Article
Review
Langues
eng
Pagination
103237Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
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