Coronary Artery Calcifications and Cardiac Risk After Radiation Therapy for Stage III Lung Cancer.
Journal
International journal of radiation oncology, biology, physics
ISSN: 1879-355X
Titre abrégé: Int J Radiat Oncol Biol Phys
Pays: United States
ID NLM: 7603616
Informations de publication
Date de publication:
01 01 2022
01 01 2022
Historique:
received:
28
04
2021
revised:
02
07
2021
accepted:
09
08
2021
pubmed:
23
8
2021
medline:
8
3
2022
entrez:
22
8
2021
Statut:
ppublish
Résumé
Heart dose and heart disease increase the risk for cardiac toxicity associated with radiation therapy. We hypothesized that computed tomography (CT) coronary calcifications are associated with cardiac toxicity and may help ascertain baseline heart disease. We analyzed the cumulative incidence of cardiac events in patients with stage III non-small cell lung cancer receiving median 74 Gy on prospective dose-escalation trials. Events were defined as symptomatic effusion, pericarditis, unstable angina, infarction, significant arrhythmia, and/or heart failure. Coronary calcifications were delineated on simulation CTs using radiation software program (130 HU threshold). Calcifications were defined as "none," "low," and "high," with median volume dividing low and high. Of 109 patients, 26 had cardiac events at median 26 months (range, 1-84 months) after radiation therapy. Median follow-up in surviving patients was 8.8 years (range, 2.3-17.3). On simulation CTs, 64 patients (59%) had coronary calcifications with median volume 0.2 cm The presence of coronary calcifications is a cardiac risk factor that can identify high-risk patients for medical referral and help guide clinicians before potentially cardiotoxic cancer treatments.
Identifiants
pubmed: 34419565
pii: S0360-3016(21)02705-X
doi: 10.1016/j.ijrobp.2021.08.017
pmc: PMC8688314
mid: NIHMS1745342
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
188-196Subventions
Organisme : NCI NIH HHS
ID : R01 CA069579
Pays : United States
Organisme : NCI NIH HHS
ID : R29 CA069579
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
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