Influence of epileptogenic region on brain structural changes in Rolandic epilepsy.
Granger causality analysis
MRI
Rolandic epilepsy
Structural covariance
Journal
Brain imaging and behavior
ISSN: 1931-7565
Titre abrégé: Brain Imaging Behav
Pays: United States
ID NLM: 101300405
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
accepted:
18
07
2021
pubmed:
23
8
2021
medline:
11
2
2022
entrez:
22
8
2021
Statut:
ppublish
Résumé
To investigate the influence of epileptogenic cortex (Rolandic areas) with executive functions in Rolandic epilepsy using structural covariance analysis of structural magnetic resonance imaging (MRI). Structural MRI data of drug-naive patients with Rolandic epilepsy (n = 70) and typically developing children as healthy controls (n = 83) were analyzed using voxel-based morphometry. Gray matter volumes in the patients were compared with those of healthy controls, and were further correlated with epilepsy duration and cognitive score of executive function, respectively. By applying Granger causal analysis to the sequenced morphometric data according to disease progression information, causal network of structural covariance was constructed to assess the causal influence of structural changes from Rolandic cortices to the regions engaging executive function in the patients. Compared with healthy controls, epilepsy patients showed increased gray matter volume in the Rolandic regions, and also the regions engaging in executive function. Covariance network analyses showed that along with disease progression, the Rolandic regions imposed positive causal influence on the regions engaging in executive function. In the patients with Rolandic epilepsy, epileptogenic regions have causal influence on the structural changes in the regions of executive function, implicating damaging effects of Rolandic epilepsy on human brain.
Identifiants
pubmed: 34420145
doi: 10.1007/s11682-021-00517-5
pii: 10.1007/s11682-021-00517-5
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
424-434Subventions
Organisme : 863 Project
ID : 2014BAI04B05
Organisme : 863 Project
ID : 2015AA020505
Organisme : National Natural Science Foundation of China
ID : 81871345
Organisme : National Natural Science Foundation of China
ID : 81701680
Organisme : National Natural Science Foundation of China
ID : 81790653
Organisme : National Natural Science Foundation of China
ID : 81422022
Organisme : National Natural Science Foundation of China
ID : 81271553
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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