Photoreactive Molecular Glue for Enhancing the Efficacy of DNA Aptamers by Temporary-to-Permanent Conjugation with Target Proteins.

Aptamers, Nucleotide / chemistry Azides / chemistry Benzophenones / chemistry Cell Line, Tumor Cell Movement Hepatocyte Growth Factor / chemistry Humans Microscopy, Confocal Phosphorylation Protein Binding Proto-Oncogene Proteins c-met / chemistry Ultraviolet Rays

Journal

Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056

Informations de publication

Date de publication:
01 09 2021
Historique:
pubmed: 24 8 2021
medline: 3 2 2022
entrez: 23 8 2021
Statut: ppublish

Résumé

We developed a photoreactive molecular glue,

Identifiants

DOI: 10.1021/jacs.1c06816 PMID: 34424707
pubmed: 34424707
doi: 10.1021/jacs.1c06816
doi:

Substances chimiques

Aptamers, Nucleotide 0
Azides 0
Benzophenones 0
Hepatocyte Growth Factor 67256-21-7
benzophenone 701M4TTV9O
Proto-Oncogene Proteins c-met EC 2.7.10.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

13937-13943

Auteurs

Ai Kohata (A)

Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

Ryosuke Ueki (R)

Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
ORCID: 0000-0002-5433-5354

Kou Okuro (K)

Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
ORCID: 0000-0003-0445-6358

P K Hashim (PK)

Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
ORCID: 0000-0001-9944-7926

Shinsuke Sando (S)

Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
ORCID: 0000-0003-0275-7237

Takuzo Aida (T)

Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Riken Center for Emergent Matter Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
ORCID: 0000-0002-0002-8017

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Polynucléotides › Oligonucléotides › Aptamères nucléotidiques › Photoreactive Molecular Glue for Enhancing the...
questionsmedicales.fr › Composés chimiques organiques › Azotures › Photoreactive Molecular Glue for Enhancing the...
questionsmedicales.fr › Composés chimiques organiques › Cétones › Benzophénones › Photoreactive Molecular Glue for Enhancing the...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Photoreactive Molecular Glue for Enhancing the...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › Photoreactive Molecular Glue for Enhancing the...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Facteur de croissance des hépatocytes › Photoreactive Molecular Glue for Enhancing the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Photoreactive Molecular Glue for Enhancing the...
questionsmedicales.fr › Techniques d'investigation › Microscopie confocale › Photoreactive Molecular Glue for Enhancing the...
questionsmedicales.fr › Métabolisme › Phosphorylation › Photoreactive Molecular Glue for Enhancing the...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Photoreactive Molecular Glue for Enhancing the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-met › Photoreactive Molecular Glue for Enhancing the...
questionsmedicales.fr › Environnement et santé publique › Environnement › Concepts météorologiques › Atmosphère › Temps (météorologie) › Lumière du soleil › Rayons ultraviolets › Photoreactive Molecular Glue for Enhancing the...