Modelling COVID-19 dynamics and potential for herd immunity by vaccination in Austria, Luxembourg and Sweden.

Bayesian inference Cross-country comparison Healthcare system Markov Chain Monte Carlo SEIR model

Journal

Journal of theoretical biology
ISSN: 1095-8541
Titre abrégé: J Theor Biol
Pays: England
ID NLM: 0376342

Informations de publication

Date de publication:
07 12 2021
Historique:
received: 02 04 2021
revised: 28 07 2021
accepted: 16 08 2021
pubmed: 24 8 2021
medline: 6 10 2021
entrez: 23 8 2021
Statut: ppublish

Résumé

Against the COVID-19 pandemic, non-pharmaceutical interventions have been widely applied and vaccinations have taken off. The upcoming question is how the interplay between vaccinations and social measures will shape infections and hospitalizations. Hence, we extend the Susceptible-Exposed-Infectious-Removed (SEIR) model including these elements. We calibrate it to data of Luxembourg, Austria and Sweden until 15 December 2020. Sweden results having the highest fraction of undetected, Luxembourg of infected and all three being far from herd immunity in December. We quantify the level of social interaction, showing that a level around 1/3 of before the pandemic was still required in December to keep the effective reproduction number R

Identifiants

pubmed: 34425136
pii: S0022-5193(21)00293-9
doi: 10.1016/j.jtbi.2021.110874
pmc: PMC8378986
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

110874

Subventions

Organisme : NIGMS NIH HHS
ID : P41 GM103426
Pays : United States

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Françoise Kemp (F)

University of Luxembourg, Luxembourg Centre for Systems Biomedicine, 6 Av. du Swing, 4367 Belvaux, Luxembourg. Electronic address: francoise.kemp@uni.lu.

Daniele Proverbio (D)

University of Luxembourg, Luxembourg Centre for Systems Biomedicine, 6 Av. du Swing, 4367 Belvaux, Luxembourg. Electronic address: daniele.proverbio@uni.lu.

Atte Aalto (A)

University of Luxembourg, Luxembourg Centre for Systems Biomedicine, 6 Av. du Swing, 4367 Belvaux, Luxembourg. Electronic address: atte.aalto@uni.lu.

Laurent Mombaerts (L)

University of Luxembourg, Luxembourg Centre for Systems Biomedicine, 6 Av. du Swing, 4367 Belvaux, Luxembourg. Electronic address: laurent.mombaerts@uni.lu.

Aymeric Fouquier d'Hérouël (A)

University of Luxembourg, Luxembourg Centre for Systems Biomedicine, 6 Av. du Swing, 4367 Belvaux, Luxembourg. Electronic address: aymeric.dherouel@uni.lu.

Andreas Husch (A)

University of Luxembourg, Luxembourg Centre for Systems Biomedicine, 6 Av. du Swing, 4367 Belvaux, Luxembourg. Electronic address: andreas.husch@uni.lu.

Christophe Ley (C)

University of Ghent, Department of Applied Mathematics, Computer Science and Statistics, Krijgslaan 281-S9, 9000 Ghent, Belgium. Electronic address: christophe.ley@ugent.be.

Jorge Gonçalves (J)

University of Luxembourg, Luxembourg Centre for Systems Biomedicine, 6 Av. du Swing, 4367 Belvaux, Luxembourg; University of Cambridge, Department of Plant Sciences, Downing St, Cambridge CB2 3EA, United Kingdom. Electronic address: jorge.goncalves@uni.lu.

Alexander Skupin (A)

University of Luxembourg, Luxembourg Centre for Systems Biomedicine, 6 Av. du Swing, 4367 Belvaux, Luxembourg; University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093, United States. Electronic address: alexander.skupin@uni.lu.

Stefano Magni (S)

University of Luxembourg, Luxembourg Centre for Systems Biomedicine, 6 Av. du Swing, 4367 Belvaux, Luxembourg. Electronic address: stefano.magni@uni.lu.

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