Metagenome-wide association study revealed disease-specific landscape of the gut microbiome of systemic lupus erythematosus in Japanese.
Adult
Female
Gastrointestinal Microbiome
/ genetics
Genes, Bacterial
/ genetics
Genome-Wide Association Study
Humans
Japan
Lupus Erythematosus, Systemic
/ genetics
Male
Metabolic Networks and Pathways
/ genetics
Metagenome
Metagenomics
Middle Aged
Streptococcus anginosus
/ genetics
Streptococcus intermedius
/ genetics
autoimmune diseases
autoimmunity
lupus erythematosus
systemic
Journal
Annals of the rheumatic diseases
ISSN: 1468-2060
Titre abrégé: Ann Rheum Dis
Pays: England
ID NLM: 0372355
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
29
04
2021
accepted:
20
07
2021
pubmed:
25
8
2021
medline:
15
12
2021
entrez:
24
8
2021
Statut:
ppublish
Résumé
Alteration of the gut microbiome has been linked to the pathogenesis of systemic lupus erythematosus (SLE). However, a comprehensive view of the gut microbiome in SLE and its interaction with the host remains to be revealed. This study aimed to reveal SLE-associated changes in the gut microbiome and its interaction with the host by a comprehensive metagenome-wide association study (MWAS) followed by integrative analysis. We performed a MWAS of SLE based on shotgun sequencing of the gut microbial DNA from Japanese individuals ( Via species level phylogenetic analysis, we identified and validated increases of Our MWAS followed by integrative analysis revealed SLE-associated changes in the gut microbiome and its interaction with the host, which contribute to our understanding of the relationship between the microbiome and SLE.
Identifiants
pubmed: 34426398
pii: annrheumdis-2021-220687
doi: 10.1136/annrheumdis-2021-220687
pmc: PMC8600607
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1575-1583Informations de copyright
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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