Mass spectrometry analysis of saponins.
glycan
imaging
ion mobility
natural product
saponin
Journal
Mass spectrometry reviews
ISSN: 1098-2787
Titre abrégé: Mass Spectrom Rev
Pays: United States
ID NLM: 8219702
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
revised:
13
07
2021
received:
25
03
2021
accepted:
09
08
2021
medline:
11
4
2023
pubmed:
26
8
2021
entrez:
25
8
2021
Statut:
ppublish
Résumé
Saponins are amphiphilic molecules of pharmaceutical interest and most of their biological activities (i.e., cytotoxic, hemolytic, fungicide, etc.) are associated to their membranolytic properties. These molecules are secondary metabolites present in numerous plants and in some marine animals, such as sea cucumbers and starfishes. Structurally, all saponins correspond to the combination of a hydrophilic glycan, consisting of sugar chain(s), linked to a hydrophobic triterpenoidic or steroidic aglycone, named the sapogenin. Saponins present a high structural diversity and their structural characterization remains extremely challenging. Ideally, saponin structures are best established using nuclear magnetic resonance experiments conducted on isolated molecules. However, the extreme structural diversity of saponins makes them challenging from a structural analysis point of view since, most of the time, saponin extracts consist in a huge number of congeners presenting only subtle structural differences. In the present review, we wish to offer an overview of the literature related to the development of mass spectrometry for the study of saponins. This review will demonstrate that most of the past and current mass spectrometry methods, including electron, electrospray and matrix-assisted laser desorption/ionization ionizations, gas/liquid chromatography coupled to (tandem) mass spectrometry, collision-induced dissociation including MS
Substances chimiques
Saponins
0
Plant Extracts
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
954-983Informations de copyright
© 2021 John Wiley & Sons Ltd.
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