Pro-inflammatory β cell small extracellular vesicles induce β cell failure through activation of the CXCL10/CXCR3 axis in diabetes.

Animals CD8-Positive T-Lymphocytes / immunology Chemokine CXCL10 / metabolism Diabetes Mellitus / pathology Extracellular Vesicles / metabolism Insulin-Secreting Cells / metabolism Macrophages / metabolism Male Mice, Inbred C57BL Receptors, CXCR3 / metabolism
CXCL10 diabetes extracellular vesicles inflammation intercellular communication islet β cell

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
24 08 2021
Historique:
received: 21 12 2020
revised: 04 06 2021
accepted: 05 08 2021
entrez: 25 8 2021
pubmed: 26 8 2021
medline: 12 2 2022
Statut: ppublish

Résumé

Coordinated communication among pancreatic islet cells is necessary for maintenance of glucose homeostasis. In diabetes, chronic exposure to pro-inflammatory cytokines has been shown to perturb β cell communication and function. Compelling evidence has implicated extracellular vesicles (EVs) in modulating physiological and pathological responses to β cell stress. We report that pro-inflammatory β cell small EVs (cytokine-exposed EVs [cytoEVs]) induce β cell dysfunction, promote a pro-inflammatory islet transcriptome, and enhance recruitment of CD8

Identifiants

DOI: 10.1016/j.celrep.2021.109613 PMID: 34433033 PMC: PMC8420815
pubmed: 34433033
pii: S2211-1247(21)01051-2
doi: 10.1016/j.celrep.2021.109613
pmc: PMC8420815
mid: NIHMS1735658
pii:
doi:

Substances chimiques

Chemokine CXCL10 0
Cxcl10 protein, mouse 0
Cxcr3 protein, mouse 0
Receptors, CXCR3 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

109613

Subventions

Organisme : NIDDK NIH HHS
ID : F99 DK123834
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK098468
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL105355
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

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Auteurs

Naureen Javeed (N)

Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA. Electronic address: javeed.naureen@mayo.edu.

Tracy K Her (TK)

Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.

Matthew R Brown (MR)

Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.

Patrick Vanderboom (P)

Division of Endocrinology, Diabetes, and Metabolism, Mayo Clinic, Rochester, MN 55905, USA.

Kuntol Rakshit (K)

Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.

Aoife M Egan (AM)

Division of Endocrinology, Diabetes, and Metabolism, Mayo Clinic, Rochester, MN 55905, USA.

Adrian Vella (A)

Division of Endocrinology, Diabetes, and Metabolism, Mayo Clinic, Rochester, MN 55905, USA.

Ian Lanza (I)

Division of Endocrinology, Diabetes, and Metabolism, Mayo Clinic, Rochester, MN 55905, USA.

Aleksey V Matveyenko (AV)

Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA; Division of Endocrinology, Diabetes, and Metabolism, Mayo Clinic, Rochester, MN 55905, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Pro-inflammatory β cell small extracellular...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Pro-inflammatory β cell small extracellular...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Chimiokines › Chimiokines CXC › Chimiokine CXCL10 › Pro-inflammatory β cell small extracellular...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Pro-inflammatory β cell small extracellular...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Vésicules extracellulaires › Pro-inflammatory β cell small extracellular...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules entéroendocrines › Cellules à insuline › Pro-inflammatory β cell small extracellular...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Pro-inflammatory β cell small extracellular...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Pro-inflammatory β cell small extracellular...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux chimiokines › Récepteurs CXCR › Récepteurs CXCR3 › Pro-inflammatory β cell small extracellular...