p16
CAR T cells
T cells
adoptive immunotherapy
cellular senescence
exhaustion and activation markers
p16INK4a
p38MAPK
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
21
04
2021
accepted:
20
07
2021
entrez:
26
8
2021
pubmed:
27
8
2021
medline:
15
12
2021
Statut:
epublish
Résumé
T-cell dysfunction arising upon repeated antigen exposure prevents effective immunity and immunotherapy. Using various clinically and physiologically relevant systems, we show that a prominent feature of PD-1-expressing exhausted T cells is the development of cellular senescence features both
Identifiants
pubmed: 34434190
doi: 10.3389/fimmu.2021.698565
pmc: PMC8381277
doi:
Substances chimiques
CDKN2A protein, human
0
Cyclin-Dependent Kinase Inhibitor p16
0
PDCD1 protein, human
0
Programmed Cell Death 1 Receptor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
698565Subventions
Organisme : CIHR
ID : PJT-152988
Pays : Canada
Organisme : CIHR
ID : PJT-156133
Pays : Canada
Informations de copyright
Copyright © 2021 Janelle, Neault, Lebel, De Sousa, Boulet, Durrieu, Carli, Muzac, Lemieux, Labrecque, Melichar, Mallette and Delisle.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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