Plasmatic Hippuric Acid as a Hallmark of Frailty in an Italian Cohort: The Mediation Effect of Fruit-Vegetable Intake.
Frailty
Fruit–vegetable intakes
Hippuric acid
Mass spectrometry
Metabolism
Journal
The journals of gerontology. Series A, Biological sciences and medical sciences
ISSN: 1758-535X
Titre abrégé: J Gerontol A Biol Sci Med Sci
Pays: United States
ID NLM: 9502837
Informations de publication
Date de publication:
15 11 2021
15 11 2021
Historique:
received:
07
05
2021
pubmed:
27
8
2021
medline:
18
3
2022
entrez:
26
8
2021
Statut:
ppublish
Résumé
Frailty syndrome is an age-related condition involving a loss of resilience, susceptibility to adverse health outcomes, and poor quality of life. This study was conducted in the framework of InveCe.Ab, an ongoing longitudinal population-based study. Plasma from 130 older individuals (older adults aged 76-78 years) was analyzed and validated (on 303 participants) using mass spectrometry-based metabolomics approaches. Equivalence tests showed that metabolites from the central cellular metabolic pathways were equivalent in frail and fit participants. Hippuric acid was the only cometabolite that distinguished fit from frail older adults. Logistic regression analysis indicated that high hippuric acid levels are significantly associated with a reduction of the risk of frailty after 4 years. Mediation analysis using a Frailty Index, hippuric acid, and fruit-vegetable intake supported the role of fruit-vegetable consumption in the hippuric acid relationship with the Frailty Index. These data point to low plasma hippuric acid as a plausible hallmark of frailty status, associated with lower fruit-vegetable intakes.
Identifiants
pubmed: 34436596
pii: 6357993
doi: 10.1093/gerona/glab244
pmc: PMC8599087
doi:
Substances chimiques
Hippurates
0
hippuric acid
TE0865N2ET
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2081-2089Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America.
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