Association of Polygenic Risk Score and Bacterial Toxins at Screening Colonoscopy with Colorectal Cancer Progression: A Multicenter Case-Control Study.
Adult
Aged
Aged, 80 and over
Bacterial Toxins
/ genetics
Case-Control Studies
Colonoscopy
/ statistics & numerical data
Colorectal Neoplasms
/ chemically induced
Disease Progression
Enterotoxigenic Escherichia coli
Enterotoxins
Female
Gastrointestinal Microbiome
/ drug effects
Healthy Volunteers
Host-Pathogen Interactions
/ drug effects
Humans
Male
Middle Aged
Multifactorial Inheritance
/ genetics
Risk Factors
Young Adult
bacterial protein toxins
colorectal cancer
gut microbiota screening
host–pathogens interaction
mucosa adherent bacteria
polygenic risk score
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
16 08 2021
16 08 2021
Historique:
received:
21
07
2021
revised:
06
08
2021
accepted:
11
08
2021
entrez:
26
8
2021
pubmed:
27
8
2021
medline:
27
1
2022
Statut:
epublish
Résumé
Colorectal cancer (CRC) is a leading cause of cancer death worldwide, and its incidence is correlated with infections, chronic inflammation, diet, and genetic factors. An emerging aspect is that microbial dysbiosis and chronic infections triggered by certain bacteria can be risk factors for tumor progression. Recent data suggest that certain bacterial toxins implicated in DNA attack or in proliferation, replication, and death can be risk factors for insurgence and progression of CRC. In this study, we recruited more than 300 biopsy specimens from people undergoing colonoscopy, and we analyzed to determine whether a correlation exists between the presence of bacterial genes coding for toxins possibly involved in CRC onset and progression and the different stages of CRC. We also analyzed to determine whether CRC-predisposing genetic factors could contribute to bacterial toxins response. Our results showed that CIF toxin is associated with polyps or adenomas, whereas pks+ seems to be a predisposing factor for CRC. Toxins from
Identifiants
pubmed: 34437440
pii: toxins13080569
doi: 10.3390/toxins13080569
pmc: PMC8402601
pii:
doi:
Substances chimiques
Bacterial Toxins
0
Enterotoxins
0
Types de publication
Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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